{"doi":"10.1016/j.molcel.2010.02.040","title":"SWI/SNF Has Intrinsic Nucleosome Disassembly Activity that Is Dependent on Adjacent Nucleosomes","abstract":null,"journal":"Molecular Cell","year":2010,"id":593610,"datarank":0.7747178960885273,"base_score":5.1647859739235145,"endowment":5.1647859739235145,"self_citation_contribution":0.7747178960885273,"citation_network_contribution":0.0,"self_endowment_contribution":0.7747178960885273,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":174,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1519304,"name":"Abdellah Sabri","orcid":null,"position":1,"is_corresponding":false},{"id":719734,"name":"Santhi Pondugula","orcid":"0000-0002-3762-7312","position":2,"is_corresponding":false},{"id":809816,"name":"Stefan R. Kassabov","orcid":null,"position":3,"is_corresponding":false},{"id":576854,"name":"Nilanjana Chatterjee","orcid":"0000-0002-1203-5222","position":4,"is_corresponding":false},{"id":447551,"name":"Michael P. Kladde","orcid":"0000-0001-7951-9291","position":5,"is_corresponding":false},{"id":44964,"name":"Blaine Bartholomew","orcid":"0000-0003-4014-9750","position":6,"is_corresponding":false},{"id":135558,"name":"Mekonnen Lemma Dechassa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"SWI/SNF Has Intrinsic Nucleosome Disassembly Activity that Is Dependent on Adjacent Nucleosomes","abstract":"The ATP-dependent chromatin remodeling complex SWI/SNF regulates transcription and has been implicated in promoter nucleosome eviction. Efficient nucleosome disassembly by SWI/SNF alone in biochemical assays, however, has not been directly observed. Employing a model system of dinucleosomes rather than mononucleosomes, we demonstrate that remodeling leads to ordered and efficient disassembly of one of the two nucleosomes. An H2A/H2B dimer is first rapidly displaced, and then, in a slower reaction, an entire histone octamer is lost. Nucleosome disassembly by SWI/SNF did not require additional factors such as chaperones or acceptors of histones. Observations in single molecules as well as bulk measurement suggest that a key intermediate in this process is one in which a nucleosome is moved toward the adjacent nucleosome. SWI/SNF recruited by the transcriptional activator Gal4-VP16 preferentially mobilizes the proximal nucleosome and destabilizes the adjacent nucleosome.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20513433","pmcid":"PMC3161732","openalex_id":null,"authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"CA 95525","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM048413","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM 48413","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA095525","title":null}],"total_grants":4,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":"https://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"http://www.cell.com/article/S1097276510003229/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1097276510003229?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1097276510003229?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Nucleosomes","Chromosomal Proteins, Non-Histone","Transcription Factors","Chromosome Mapping","Transcription, Genetic","Models, Molecular","Promoter Regions, Genetic"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T11:38:08.120683Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}