{"doi":"10.1016/j.molcel.2007.06.028","title":"A Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine Kinases","abstract":null,"journal":"Molecular Cell","year":2007,"id":667468,"datarank":0.8530463034509732,"base_score":5.68697535633982,"endowment":5.68697535633982,"self_citation_contribution":0.8530463034509732,"citation_network_contribution":0.0,"self_endowment_contribution":0.8530463034509732,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":294,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":10,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":346894,"name":"Jinghong Ma","orcid":"0000-0002-3458-1363","position":1,"is_corresponding":false},{"id":397968,"name":"Wanqing Li","orcid":"0000-0001-6432-5195","position":2,"is_corresponding":false},{"id":1743037,"name":"Anna V. Eliseenkova","orcid":null,"position":3,"is_corresponding":false},{"id":1525513,"name":"Chongfeng Xu","orcid":null,"position":4,"is_corresponding":false},{"id":291560,"name":"Thomas A. Neubert","orcid":"0000-0001-7049-2088","position":5,"is_corresponding":false},{"id":1743038,"name":"W. Todd Miller","orcid":null,"position":6,"is_corresponding":false},{"id":61497,"name":"Moosa Mohammadi","orcid":"0000-0003-2434-9437","position":7,"is_corresponding":false},{"id":349129,"name":"Huaibin Chen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine Kinases","abstract":"Activating mutations in the tyrosine kinase domain of receptor tyrosine kinases (RTKs) cause cancer and skeletal disorders. Comparison of the crystal structures of unphosphorylated and phosphorylated wild-type FGFR2 kinase domains with those of seven unphosphorylated pathogenic mutants reveals an autoinhibitory \"molecular brake\" mediated by a triad of residues in the kinase hinge region of all FGFRs. Structural analysis shows that many other RTKs, including PDGFRs, VEGFRs, KIT, CSF1R, FLT3, TEK, and TIE, are also subject to regulation by this brake. Pathogenic mutations activate FGFRs and other RTKs by disengaging the brake either directly or indirectly.","is_dataset_classified":null,"base_score":5.68697535633982,"endowment":5.68697535633982,"datacite_reuse_total":10,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17803937","pmcid":"PMC2094128","openalex_id":"https://openalex.org/W2132437319","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"CA58530","title":null},{"funder_name":"NIDCR NIH HHS","grant_id":"R01 DE013686","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA016087","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA058530","title":null},{"funder_name":"NIDCR NIH HHS","grant_id":"DE13686","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"S10 RR017990","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"P30 NS050276","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01CA058530-22","title":"Substrate Specificity of Non-receptor Tyrosine Kinases"},{"funder_name":"National Institutes of Health","grant_id":"3R01DE013686-13S1","title":"Mechanisms of FGF Receptor Regulation and Signaling"},{"funder_name":"National Institutes of Health","grant_id":"1S10RR017990-01","title":"Q-TOF Mass Spectrometer"},{"funder_name":"National Institutes of Health","grant_id":"5P30CA016087-32","title":"Experimental Pathology"},{"funder_name":"National Institutes of Health","grant_id":"5P30NS050276-02","title":"Protein Mass Spectrometry Core Facility for Neuroscience"}],"total_grants":12,"fwci":9.1948,"citation_percentile":0.9877397,"influential_citations":0,"citation_trend":[{"year":2012,"count":10},{"year":2013,"count":13},{"year":2014,"count":19},{"year":2015,"count":18},{"year":2016,"count":17},{"year":2017,"count":9},{"year":2018,"count":11},{"year":2019,"count":14},{"year":2020,"count":15},{"year":2021,"count":15},{"year":2022,"count":14},{"year":2023,"count":31},{"year":2024,"count":30},{"year":2025,"count":12},{"year":2026,"count":5}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.cell.com/article/S1097276507004406/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S1097276507004406/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1097276507004406?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1097276507004406?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.molcel.2007.06.028","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17803937","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2094128","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.molcel.2007.06.028","host_type":""},{"url":"https://dx.doi.org/10.1016/j.molcel.2007.06.028","host_type":""}],"fields_of_study":["Gastrointestinal Tumor Research and Treatment","HER2/EGFR in Cancer Research","Chronic Lymphocytic Leukemia Research","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Amino Acid Sequence","Enzyme Activation","Humans","Hydrogen Bonding","Models, Molecular","Molecular Sequence Data","Mutation","Phosphorylation","Sequence Alignment","Protein Structure, Tertiary","Crystallography, X-Ray","Receptor, Fibroblast Growth Factor, Type 2"],"keywords":["Biology","Kinase","Receptor tyrosine kinase","Tyrosine kinase","Tropomyosin receptor kinase C","Cell biology","ROR1","Hinge","Receptor Protein-Tyrosine Kinases","Proto-oncogene tyrosine-protein kinase Src","Receptor","Biochemistry","Platelet-derived growth factor receptor","Signal transduction","Models, Molecular","Molecular Sequence Data","Hydrogen Bonding","Crystallography, X-Ray","Protein Structure, Tertiary","Enzyme Activation","Mutation","Humans","Amino Acid Sequence","Phosphorylation","Receptor, Fibroblast Growth Factor, Type 2","Molecular Biology","Sequence Alignment"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.19687105.v1","title":"Additional file 1 of FGFR1 is a potential therapeutic target in neuroblastoma","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.19687105","title":"Additional file 1 of FGFR1 is a potential therapeutic target in neuroblastoma","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.22601515.v1","title":"Additional file 1 of Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.22601515","title":"Additional file 1 of Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.22616258.v1","title":"Additional file 1 of Integrated multi-omic analysis of low-grade ovarian serous carcinoma collected from short and long-term survivors","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.22616258","title":"Additional file 1 of Integrated multi-omic analysis of low-grade ovarian serous carcinoma collected from short and long-term survivors","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.25522688.v1","title":"Additional file 1 of Genetic insights into the ‘sandwich fusion’ subtype of Klippel–Feil syndrome: novel FGFR2 mutations identified by 21 cases of whole-exome sequencing","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.25522688","title":"Additional file 1 of Genetic insights into the ‘sandwich fusion’ subtype of Klippel–Feil syndrome: novel FGFR2 mutations identified by 21 cases of whole-exome sequencing","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.22616261","title":"Additional file 2 of Integrated multi-omic analysis of low-grade ovarian serous carcinoma collected from short and long-term survivors","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.22616261.v1","title":"Additional file 2 of Integrated multi-omic analysis of low-grade ovarian serous carcinoma collected from short and long-term survivors","publisher":"figshare","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T17:56:58.775951Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}