{"doi":"10.1016/j.mod.2010.11.002","title":"Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity","abstract":null,"journal":"Mechanisms of Development","year":2011,"id":636911,"datarank":0.6238324625039509,"base_score":4.1588830833596715,"endowment":4.1588830833596715,"self_citation_contribution":0.6238324625039509,"citation_network_contribution":0.0,"self_endowment_contribution":0.6238324625039509,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":63,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1292377,"name":"Wei Lin","orcid":"0000-0002-0455-8752","position":1,"is_corresponding":false},{"id":1653484,"name":"Emmanouil Metzakopian","orcid":null,"position":2,"is_corresponding":false},{"id":1653485,"name":"Anna L.M. Ferri","orcid":null,"position":3,"is_corresponding":false},{"id":108270,"name":"Carol H. Yan","orcid":"0000-0003-1934-4922","position":4,"is_corresponding":false},{"id":424657,"name":"Hiroshi Sasaki","orcid":"0000-0002-6458-5330","position":5,"is_corresponding":false},{"id":1653488,"name":"Jeff Whisett","orcid":null,"position":6,"is_corresponding":false},{"id":1653489,"name":"Siew-Lan Ang","orcid":null,"position":7,"is_corresponding":false},{"id":1653483,"name":"Yannis E. Mavromatakis","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity","abstract":"Foxa2, a member of the Foxa family of forkhead/winged helix family of transcription factors, has previously been shown to be an upstream positive regulator of Shh expression in many different tissues. Recent studies also strongly suggest that Foxa2 specify cell fate by inhibiting the expression of cell fate determinants such as Helt1 and Nkx2.2. In this paper, phenotypic analyses of Wnt1cre; Foxa2flox/flox embryos in the midbrain have demonstrated a novel role for Foxa2 and its related family member, Foxa1, to attenuate Shh signalling by inhibiting the expression of its intracellular transducer, Gli2, at the transcriptional level. Chromatin immunoprecipitation experiments indicate that Foxa2 binds to genomic regions of Gli2 and likely regulates its expression in a direct manner. Our studies, involving loss and gain of function studies in mice, also provided further insights into the gene regulatory interactions among Foxa1, Foxa2 and Shh in ventral midbrain progenitors that contribute to midbrain patterning. Altogether, these data indicate that Foxa1 and Foxa2 contribute to the specification of ventral midbrain progenitor identity by regulating Shh signalling in a positive and negative manner.","is_dataset_classified":null,"base_score":4.1588830833596715,"endowment":4.1588830833596715,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21093585","pmcid":null,"openalex_id":"https://openalex.org/W2024442264","authors":[],"funders":[{"funder_name":"Medical Research Council","grant_id":"MC_U117570533","title":null}],"total_grants":1,"fwci":1.8673,"citation_percentile":0.84705144,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":7},{"year":2014,"count":6},{"year":2015,"count":6},{"year":2016,"count":1},{"year":2017,"count":5},{"year":2018,"count":4},{"year":2019,"count":5},{"year":2020,"count":6},{"year":2021,"count":1},{"year":2022,"count":5},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"bronze","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0925477310000821/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0925477310000821/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0925477310000821?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0925477310000821?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.mod.2010.11.002","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21093585","host_type":"repository"}],"fields_of_study":["Developmental Biology and Gene Regulation","Congenital heart defects research","MicroRNA in disease regulation"],"mesh_terms":["Zinc Finger Protein GLI1","Patched Receptors","Zinc Finger Protein Gli2","Homeobox Protein Nkx-2.2","Animals","Base Sequence","Embryo, Mammalian","Mesencephalon","Models, Biological","Molecular Sequence Data","Neurons","Protein Binding","Receptors, Cell Surface","Stem Cells","Transcription Factors","Signal Transduction","Genome","Conserved Sequence","Homeodomain Proteins","Gene Expression Regulation, Developmental","Zebrafish Proteins","Mice","Hepatocyte Nuclear Factor 3-alpha","Hepatocyte Nuclear Factor 3-beta","Kruppel-Like Transcription Factors","Hedgehog Proteins"],"keywords":["FOXA2","FOXA1","Biology","GLI2","Transcription factor","Progenitor","Chromatin immunoprecipitation","Cell biology","Forkhead Transcription Factors","Sonic hedgehog","Cell fate determination","Progenitor cell","Genetics","Signal transduction","Gene expression","Gene","Stem cell","Promoter"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T17:57:18.735858Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}