{"doi":"10.1016/j.mitoco.2023.09.001","title":"TELP theory: Elucidating the major observations of Rieger et al. 2021 in mitochondria","abstract":null,"journal":"Mitochondrial Communications","year":2023,"id":621984,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1593352,"name":"James Weifu Lee","orcid":"0000-0003-2525-5870","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"TELP theory: Elucidating the major observations of Rieger et al. 2021 in mitochondria","abstract":"The transmembrane-electrostatically localized protons (TELP) theory may represent a complementary development to Mitchell's chemiosmotic theory. The combination of the two together can now excellently explain the energetics in mitochondria. Our calculated transmembrane-attractive force between an excess proton and an excess hydroxide explains how TELP may stay within a 1-nm thin layer at the liquid-membrane interface. Consequently, any pH sensor (sEcGFP) located at least 2–3 nm away from the membrane surface will not be able to see TELP. This feature as predicted from the TELP model was observed exactly in the experiment of Rieger et al., 2021. In contrast to their belief “the Δp at ATP synthase is almost negligible under OXPHOS conditions”, I find, when TELP activity is included in the energy calculations, there is plenty of total protonic Gibbs free energy (ΔGT) well above the physiologically required value of −24.5 kJ mol−1 to drive ATP synthesis through FoF1-ATP synthase.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19767382","pmcid":null,"openalex_id":"https://openalex.org/W4387358763","authors":[],"funders":[],"total_grants":0,"fwci":1.3454,"citation_percentile":0.81029472,"influential_citations":0,"citation_trend":[{"year":2024,"count":5},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.mitoco.2023.09.001","host_type":"journal"},{"url":"https://doi.org/10.1016/j.mitoco.2023.09.001","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2590279223000056?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2590279223000056?httpAccept=text/plain","host_type":"publisher"},{"url":"https://digitalcommons.odu.edu/chemistry_fac_pubs/281","host_type":"repository"},{"url":"https://doaj.org/article/67e774a939a64b87b45e810a9280ed9f","host_type":"repository"}],"fields_of_study":["ATP Synthase and ATPases Research","Mitochondrial Function and Pathology","Lipid Membrane Structure and Behavior"],"mesh_terms":[],"keywords":["ATP synthase","Chemiosmosis","Bioenergetics","Mitochondrion","Transmembrane protein","Oxidative phosphorylation","Electrochemical gradient","Chemistry","Gibbs free energy","Proton","Membrane","Biophysics","Transmembrane domain","ATPase","ATP synthase gamma subunit","Biochemistry","Physics","Thermodynamics","Biology","Enzyme","Quantum mechanics","ATP hydrolysis","Receptor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T17:40:27.264717Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}