{"doi":"10.1016/j.micinf.2023.105237","title":"Staphylococcus aureus-derived virulent phenol-soluble modulin α triggers alarmin release to drive IL-36-dependent corneal inflammation","abstract":null,"journal":"Microbes and Infection","year":2024,"id":625071,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1616158,"name":"Ken Fukuda","orcid":"0000-0003-4990-6308","position":1,"is_corresponding":false},{"id":1616159,"name":"Waka Ishida","orcid":"0000-0002-3217-3059","position":2,"is_corresponding":false},{"id":1616160,"name":"Tatsuma Kishimoto","orcid":null,"position":3,"is_corresponding":false},{"id":1616161,"name":"Aozora Kuwana","orcid":null,"position":4,"is_corresponding":false},{"id":772322,"name":"Takashi Suzuki","orcid":"0000-0001-7396-348X","position":5,"is_corresponding":false},{"id":1616162,"name":"Chikara Kaito","orcid":"0000-0002-2895-3386","position":6,"is_corresponding":false},{"id":461924,"name":"Kenji Yamashiro","orcid":"0000-0001-9354-8558","position":7,"is_corresponding":false},{"id":1616157,"name":"Isana Nakajima","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Staphylococcus aureus-derived virulent phenol-soluble modulin α triggers alarmin release to drive IL-36-dependent corneal inflammation","abstract":"Methicillin-resistant Staphylococcus aureus (MRSA) isolated from patients with keratitis produces substantial amounts of phenol-soluble modulin α (PSMα). However, the role of PSMα in S. aureus keratitis remains unclear. We observed that PSMα-producing and PSMα-deficient strains could infect the cornea in our experimental mouse keratitis model; however, only the PSMα-producing strain delayed epithelial wound healing and induced stromal inflammation. PSMα induced damage to the epithelium, the release of alarmins IL-1α and IL-36α, and the expression of inflammatory chemokines by resident corneal cells in the mouse corneal organ culture. The IL-36 (but not IL-1) receptor antagonist attenuated mouse keratitis induced by PSMα-containing bacterial culture supernatants, as well as by infection with PSMα-producing S. aureus, suggesting that the corneal inflammations were dependent on IL-36. Recombinant PSMα elicited IL-36-dependent corneal inflammation in mice. Thus, PSMα and the subsequently released IL-36 are critical factors triggering inflammation during S. aureus keratitis.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37805122","pmcid":null,"openalex_id":"https://openalex.org/W4387378548","authors":[],"funders":[{"funder_name":"Japan Society for the Promotion of Science","grant_id":"JP 21K09744","title":null}],"total_grants":1,"fwci":0.4243,"citation_percentile":0.56432833,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1286457923001405?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1286457923001405?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.micinf.2023.105237","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37805122","host_type":"repository"}],"fields_of_study":["NF-κB Signaling Pathways","Antimicrobial Resistance in Staphylococcus","Cell Adhesion Molecules Research","Humans","Animals","Mice","Staphylococcus aureus","Methicillin-Resistant Staphylococcus aureus","Alarmins","Staphylococcal Infections","Keratitis","Inflammation","Bacterial Toxins"],"mesh_terms":["Alarmins","Animals","Bacterial Toxins","Humans","Inflammation","Keratitis","Staphylococcal Infections","Staphylococcus aureus","Mice","Methicillin-Resistant Staphylococcus aureus"],"keywords":["Keratitis","Staphylococcus aureus","Microbiology","Corneal inflammation","Inflammation","Corneal epithelium","Biology","Chemokine","Cornea","corneal ulcer","Immunology","Corneal ulceration","Wound healing","Bacteria","Virulence","Alarmins","Interleukin 36","Phenol-soluble Modulin Α"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T05:43:43.727839Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}