{"doi":"10.1016/j.micinf.2022.105021","title":"Tim-3 expression is induced by mycobacterial antigens and identifies tissue-resident subsets of MAIT cells from patients with tuberculosis","abstract":null,"journal":"Microbes and Infection","year":2023,"id":613196,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":442115,"name":"Zhihong Cao","orcid":"0000-0002-6066-1834","position":1,"is_corresponding":false},{"id":728772,"name":"Li Xiao","orcid":"0000-0002-8929-8047","position":2,"is_corresponding":false},{"id":1579550,"name":"Binyu Li","orcid":null,"position":3,"is_corresponding":false},{"id":1314354,"name":"Shan Yu","orcid":"0009-0008-0194-6320","position":4,"is_corresponding":false},{"id":1579551,"name":"Bingfen Yang","orcid":null,"position":5,"is_corresponding":false},{"id":725937,"name":"Yanhua Liu","orcid":"0000-0002-2737-8201","position":6,"is_corresponding":false},{"id":1579552,"name":"Fei Zhai","orcid":null,"position":7,"is_corresponding":false},{"id":1579553,"name":"Ruo Wang","orcid":null,"position":8,"is_corresponding":false},{"id":1579554,"name":"Xiaoxing Cheng","orcid":"0000-0002-7036-4286","position":9,"is_corresponding":false},{"id":1345962,"name":"Jing Jiang","orcid":"0000-0001-6320-5669","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Tim-3 expression is induced by mycobacterial antigens and identifies tissue-resident subsets of MAIT cells from patients with tuberculosis","abstract":"Tissue-resident MAIT cells in tuberculous pleural effusions, the site of tuberculosis infection, were investigated in the study. Tim-3<sup>+</sup>CD69<sup>+</sup>CD103<sup>+</sup> and CD39<sup>+</sup>CD69<sup>+</sup>CD103<sup>+</sup> tissue-resident MAIT cell subsets were identified in tuberculous pleural effusions. Tim-3 expression in MAIT cells was greatly induced and CD39 expression was elevated following ex vivo stimulation with Mycobacterium tuberculosis antigens. Mycobacterial antigen-stimulated Tim-3<sup>+</sup>CD69<sup>+</sup>CD103<sup>+</sup> tissue-resident MAIT cells had higher frequency of IFN-γ- and granzyme B-producing cells than Tim-3<sup>-</sup>CD69<sup>+</sup>CD103<sup>+</sup> subset, while CD39<sup>+</sup>CD69<sup>+</sup>CD103<sup>+</sup> MAIT cells had similar frequency of IFN-γ-positive cells but higher ratio of granzyme B-producing cells than CD39<sup>-</sup>CD69<sup>+</sup>CD103<sup>+</sup> subset. Blocking of IL-2, IL-12p70 or IL-18 but not IL-15 led to significantly reduced expression of Tim-3 compared with isotype antibody control. In contrast, CD39 expression was not influenced by any of the cytokines tested. Tim-3<sup>+</sup> MAIT cells had higher levels of lipid uptake and lipid content than Tim-3<sup>-</sup> cells. It is concluded that Tim-3<sup>+</sup>CD69<sup>+</sup>CD103<sup>+</sup> tissue-resident MAIT cells were elevated in tuberculous pleural effusions and had higher capacity to produce effector molecules of IFN-γ and granzyme B.","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35811063","pmcid":null,"openalex_id":"https://openalex.org/W4284963402","authors":[],"funders":[],"total_grants":0,"fwci":0.6031,"citation_percentile":0.61591182,"influential_citations":0,"citation_trend":[{"year":2023,"count":3},{"year":2024,"count":1},{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"closed","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1286457922000910?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1286457922000910?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.micinf.2022.105021","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35811063","host_type":"repository"}],"fields_of_study":["Immune Cell Function and Interaction","Autoimmune and Inflammatory Disorders Research","Phagocytosis and Immune Regulation","Humans","Mucosal-Associated Invariant T Cells","Granzymes","Hepatitis A Virus Cellular Receptor 2","Tuberculosis","Pleural Effusion","Lipids"],"mesh_terms":["Mucosal-Associated Invariant T Cells","Hepatitis A Virus Cellular Receptor 2","Humans","Lipids","Pleural Effusion","Tuberculosis","Granzymes"],"keywords":["Granzyme B","Biology","Antigen","Immunology","Mycobacterium tuberculosis","Ex vivo","Granzyme","Tuberculosis","Perforin","In vivo","Pathology","Medicine","CD8","Immune response","TIM-3","Mucosal-associated Invariant T Cells"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T07:02:15.641377Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}