{"doi":"10.1016/j.micinf.2011.04.003","title":"Distinctive and critical roles for cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in mice","abstract":null,"journal":"Microbes and Infection","year":2011,"id":598921,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1534921,"name":"Nobuya Sasaki","orcid":null,"position":1,"is_corresponding":false},{"id":190138,"name":"Osamu Ichii","orcid":null,"position":2,"is_corresponding":false},{"id":1534923,"name":"Kiichi Kajino","orcid":null,"position":3,"is_corresponding":false},{"id":1534925,"name":"Yasuhiro Kon","orcid":null,"position":4,"is_corresponding":false},{"id":1534926,"name":"Takashi Agui","orcid":null,"position":5,"is_corresponding":false},{"id":1534920,"name":"Ayo Yila Simon","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Distinctive and critical roles for cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in mice","abstract":"Respiratory viral infections result in severe pulmonary injury, to which host immune response may be a significant contributor. At present, it is not entirely clear the extent to which lung injury is a necessary consequence of host defense. In this report, we use functional genomics approach to characterize the key roles of cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in resistant C57BL/6J and susceptible DBA/2J mice. Infected mice manifested an immune-inflammatory response characterized by the pulmonary influx of neutrophils and mononuclear cells. DBA/2J mice mounted a vigorous immune response, with significant up-regulation of cytokine/chemokine genes in two successive waves through the course of infection. Whereas, C57BL/6J mice displayed an efficient immune response with less severe pathology and clusters of immune-inflammatory responsive genes were exclusively up-regulated on day 4 in this strain. Overall, DBA/2J mice exhibited a dysregulated hyper-inflammatory cytokine/chemokine cascades that does not limit viral spread resulting in a predisposition to severe lung pathology. This response is similar to severe human respiratory paramyxovirus infections, which will serve as a model for the elucidation of hyper-immune inflammatory response that result to severe immunopathology in respiratory viral infections.","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21530676","pmcid":null,"openalex_id":"https://openalex.org/W2050374169","authors":[],"funders":[{"funder_name":"Japan Society for the Promotion of Science","grant_id":"","title":null},{"funder_name":"Ministry of Education, Culture, Sports, Science and Technology","grant_id":"","title":null}],"total_grants":2,"fwci":0.1985,"citation_percentile":0.59456461,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2015,"count":1},{"year":2017,"count":1},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2026,"count":1}],"oa_status":"green","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/46940/1/MI13-8-9_783-797.pdf","host_type":"repository"},{"url":"https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/46940/1/MI13-8-9_783-797.pdf","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S1286457911000979?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1286457911000979?httpAccept=text/plain","host_type":"publisher"},{"url":"http://hdl.handle.net/2115/46940","host_type":"repository"},{"url":"https://doi.org/10.1016/j.micinf.2011.04.003","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21530676","host_type":"repository"},{"url":"https://hdl.handle.net/2115/46940","host_type":"repository"}],"fields_of_study":["Respiratory viral infections research","Influenza Virus Research Studies","Viral Infections and Vectors"],"mesh_terms":["Analysis of Variance","Animals","Disease Models, Animal","Female","Flow Cytometry","Histocytochemistry","Immunity, Cellular","Inflammation","Lung","Mice, Inbred C57BL","Mice, Inbred DBA","Respirovirus Infections","Cluster Analysis","Disease Progression","Gene Expression Profiling","Sendai virus","Mice","Host-Pathogen Interactions"],"keywords":["Immune system","Immunology","Immunopathology","Chemokine","Biology","Sendai virus","Cytokine","Cellular immunity","Immunity","Inflammation","Innate immune system","Virus"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T16:25:01.579699Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}