{"doi":"10.1016/j.mib.2017.06.003","title":"Inhibition of CRISPR-Cas systems by mobile genetic elements","abstract":null,"journal":"Current Opinion in Microbiology","year":2017,"id":618158,"datarank":0.5570358100056463,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":0.0,"self_endowment_contribution":0.5570358100056463,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1594499,"name":"Alan R Davidson","orcid":null,"position":1,"is_corresponding":false},{"id":254500,"name":"Erik J. Sontheimer","orcid":"0000-0002-0881-0310","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Inhibition of CRISPR-Cas systems by mobile genetic elements","abstract":"Clustered, regularly interspaced, short, palindromic repeats (CRISPR) loci, together with their CRISPR-associated (Cas) proteins, provide bacteria and archaea with adaptive immunity against invasion by bacteriophages, plasmids, and other mobile genetic elements. These host defenses impart selective pressure on phages and mobile elements to evolve countermeasures against CRISPR immunity. As a consequence of this pressure, phages and mobile elements have evolved 'anti-CRISPR' proteins that function as direct inhibitors of diverse CRISPR-Cas effector complexes. Some of these CRISPR-Cas complexes can be deployed as genome engineering platforms, and anti-CRISPRs could therefore be useful in exerting spatial, temporal, or conditional control over genome editing and related applications. Here we describe the discovery of anti-CRISPRs, the range of CRISPR-Cas systems that they inhibit, their mechanisms of action, and their potential utility in biotechnology.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28668720","pmcid":"PMC5737815","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"GM115911","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"MOP-130482","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM115911","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"unidentified","title":"unidentified"}],"total_grants":4,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"Elsevier TDM","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5737815","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S1369527417300577?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1369527417300577?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.mib.2017.06.003","host_type":""},{"url":"https://europepmc.org/articles/pmc5737815?pdf=render","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/28668720","host_type":""},{"url":"https://dx.doi.org/10.1016/j.mib.2017.06.003","host_type":""},{"url":"https://doi.org/https://doi.org/20.500.14038/48829","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.mib.2017.06.003","host_type":""}],"fields_of_study":["0301 basic medicine","0303 health sciences","03 medical and health sciences","Bacteria","Bacteriophages","CRISPR-Cas Systems","Evolution, Molecular","Host-Parasite Interactions","Interspersed Repetitive Sequences"],"mesh_terms":["Bacteria","Bacteriophages","Evolution, Molecular","Interspersed Repetitive Sequences","Host-Parasite Interactions","CRISPR-Cas Systems"],"keywords":["Bacteria","Biophysics","Immunity","Genetics and Genomics","Therapeutics","Biochemistry","Microbiology","Host-Parasite Interactions","Evolution, Molecular","Interspersed Repetitive Sequences","and Structural Biology","Bacteriophages","CRISPR-Cas Systems"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T03:37:33.997778Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}