{"doi":"10.1016/j.mehy.2012.09.008","title":"Leukemia inhibitory factor receptor α-chain: A potential method for acute promyeloid leukemia therapy","abstract":null,"journal":"Medical Hypotheses","year":2012,"id":597061,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1529384,"name":"Guangkai Gao","orcid":null,"position":1,"is_corresponding":false},{"id":249571,"name":"Jun Xiong","orcid":"0000-0003-2598-0706","position":2,"is_corresponding":false},{"id":1529386,"name":"Qingtao Wu","orcid":null,"position":3,"is_corresponding":false},{"id":1529387,"name":"Houqi Liu","orcid":null,"position":4,"is_corresponding":false},{"id":445379,"name":"Qing Sun","orcid":"0000-0003-3493-9617","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Leukemia inhibitory factor receptor α-chain: A potential method for acute promyeloid leukemia therapy","abstract":"Leukemia inhibitory factor (LIF) affects multiple types of leukemia cells in vitro through its functional receptor LIFR, which comprises a complex of the LIFR α-chain (LIFRα) and gp130. Researchers have recently observed that the C-terminus of the LIFRα cytoplasmic domain contains as many conserved YXXQ motifs as gp130 (C-terminal triple YXXQ motifs, LIFRα-CT3), whose free structure has been shown to be capable of activating STAT3 phosphorylation in the cytoplasm and consequently activating STAT3-related downstream molecules in the nucleus. This process can induce pathological acute myeloid leukemia (AML) or acute promyeloid leukemia (APL) cells to differentiate into mature granulocytes, simulating the LIF-related differential cascade. This process reduces or inhibits the side effects caused by toxic all-trans retinoid acid (ATRA), which has long been used as a fundamental medication for treating AML/APL in clinical practice despite its related high relapse rate. Therefore, we believe that it is possible to maximize the beneficial effects of LIF by enriching LIFRα-CT3 in AML/APL cell cytoplasm. The aims of this work were to enrich LIFRα-specific motifs in leukemia cells using molecular biological methods and evaluate the use of membrane-permeable polypeptides as a novel possible AML/APL therapy in combination with or independent of ATRA-based chemotherapy.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23046857","pmcid":null,"openalex_id":"https://openalex.org/W2160659232","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.13303706,"influential_citations":0,"citation_trend":[{"year":2019,"count":1},{"year":2022,"count":1},{"year":2024,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0306987712004215?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0306987712004215?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.mehy.2012.09.008","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23046857","host_type":"repository"}],"fields_of_study":["Cytokine Signaling Pathways and Interactions","RNA Interference and Gene Delivery","Immune Cell Function and Interaction","Humans","Leukemia Inhibitory Factor Receptor alpha Subunit","Leukemia, Promyelocytic, Acute","Models, Theoretical"],"mesh_terms":["Humans","Models, Theoretical","Leukemia, Promyelocytic, Acute","Leukemia Inhibitory Factor Receptor alpha Subunit"],"keywords":["Leukemia inhibitory factor receptor","Leukemia inhibitory factor","Leukemia","Cancer research","Myeloid leukemia","Glycoprotein 130","Receptor","Phosphorylation","Haematopoiesis","STAT3","CD135","Cell biology","Chemistry","Biology","Stem cell","Immunology","Biochemistry","Cytokine","Interleukin 6"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T12:07:04.293108Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}