{"doi":"10.1016/j.medengphy.2020.01.004","title":"Smoothed Particle Hydrodynamics multiphase modelling of an experimental microfluidic device for conformal coating of pancreatic islets","abstract":"The paper discusses a Smoothed Particle Hydrodynamics (SPH) model for the analysis of the multiphase flow occurring in an experimental microfluidic device for conformal coating of pancreatic islets with a biocompatible and permeable polymer. The proposed numerical model, based on a weakly-compressible SPH approach, accurately mimics the encapsulation process while assuring phase conservation, thus overcoming potential limitations of grid-based models. The proposed SPH model is a triphasic multi-phase model that allows one: (i) to reproduce the physics of islet conformal coating, including the effects of surface tension at the interface of the involved fluids and of the islet diameter; and (ii) to evaluate how modulation of process parameters influences the fluid dynamics within the microfluidic device and the resulting coating characteristics. This model can represent a valuable, time- and cost-effective tool for the definition of optimized encapsulation conditions through in silico screening of novel combinations of conformal coating parameters, including polymeric coating blends, size range of insulin-secreting cell clusters, utilized chemical reagents, device geometry and scale.","journal":"Medical Engineering & Physics","year":2020,"id":111608,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.946,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":529059,"name":"Sauro Manenti","orcid":"0000-0002-5467-9640","position":1,"is_corresponding":false},{"id":529860,"name":"Tommaso Cazzato","orcid":null,"position":2,"is_corresponding":false},{"id":529060,"name":"Federica Colombo","orcid":"0000-0001-9497-0240","position":3,"is_corresponding":false},{"id":410954,"name":"Alice A. Tomei","orcid":"0000-0002-5059-6303","position":4,"is_corresponding":false},{"id":349814,"name":"Alberto Redaelli","orcid":"0000-0002-9020-2188","position":5,"is_corresponding":false},{"id":529061,"name":"Vita Manzoli","orcid":"0000-0003-3988-0386","position":6,"is_corresponding":false},{"id":529062,"name":"Filippo Consolo","orcid":"0000-0002-7948-3847","position":7,"is_corresponding":false},{"id":529058,"name":"Stefano Sibilla","orcid":"0000-0002-5541-6949","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:13:05.597252Z","pmid":"32008936","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}