{"doi":"10.1016/j.medcli.2023.03.027","title":"Papel de las estatinas en la evolución clínica de los pacientes octogenarios ingresados por COVID-19","abstract":"Introduction and objectives
coronavirus disease 2019 (COVID-19) causes high mortality in elderly patients. Some studies have shown a benefit of statin treatment in the evolution of this disease. Since there are no similar publications in this population group, the aim of this study is to analyze in-hospital mortality in relation to preadmission treatment with statins in an exclusively elderly population of octogenarian patients.Materials and methods
A single-center retrospective cohort study was performed including a total of 258 patients ≥80 years with hospital admission for confirmed COVID-19 between March 1 and May 31, 2020. They were divided into two groups: taking statins prior to admission (n=129) or not (n=129).Results
In-hospital mortality due to COVID-19 in patients ≥80 years (86.13±4.40) during the first wave was 35.7% (95% CI: 30.1-41.7%). Mortality in patients previously taking statins was 25.6% while in those not taking statins was 45.7%. Female sex (RR 0.62 [0.44-0.89]; p=0.008), diabetes (RR 0.61 [0.41-0.92]; p=0.017) and pre-admission treatment with statins (RR 0.58 95% CI [0.41-0.83]; p=0.003) were associated with lower in-hospital mortality. Severe lung involvement was associated with increased in-hospital mortality (RR 1.45 95% CI [1.04-2.03]; p=0.028). Hypertension, obesity, age, cardiovascular disease and a higher Charlson index did not, however, show influence on in-hospital mortality.Conclusions
In octogenarian patients treated with statins prior to admission for COVID-19 in the first wave, lower in-hospital mortality was observed.","journal":"Medicina Clínica","year":2023,"id":11703,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0353,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-08-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":78373,"name":"Victoria Espejo Bares","orcid":"0000-0002-9148-4914","position":1,"is_corresponding":false},{"id":78374,"name":"Verónica Artiaga de la Barrera","orcid":"0000-0002-3254-6468","position":2,"is_corresponding":false},{"id":78375,"name":"Cecilia Marco Quirós","orcid":null,"position":3,"is_corresponding":false},{"id":78376,"name":"Elia Pérez Fernández","orcid":null,"position":4,"is_corresponding":false},{"id":78377,"name":"Maria Luz Martínez Mas","orcid":null,"position":5,"is_corresponding":false},{"id":78378,"name":"Javier Botas Rodríguez","orcid":null,"position":6,"is_corresponding":false},{"id":78379,"name":"Elia Pérez‐Fernández","orcid":"0000-0003-2726-8683","position":7,"is_corresponding":false},{"id":78380,"name":"María Luz Martínez Mas","orcid":null,"position":8,"is_corresponding":false},{"id":78381,"name":"Javier Botas","orcid":"0000-0001-8871-0725","position":9,"is_corresponding":false},{"id":78372,"name":"Carla Jiménez Martínez","orcid":"0000-0003-2320-8536","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}