{"doi":"10.1016/j.mcpro.2021.100116","title":"MS-Based HLA-II Peptidomics Combined With Multiomics Will Aid the Development of Future Immunotherapies","abstract":"Immunotherapies have emerged to treat diseases by selectively modulating a patient's immune response. Although the roles of T and B cells in adaptive immunity have been well studied, it remains difficult to select targets for immunotherapeutic strategies. Because human leukocyte antigen class II (HLA-II) peptides activate CD4+ T cells and regulate B cell activation, proliferation, and differentiation, these peptide antigens represent a class of potential immunotherapy targets and biomarkers. To better understand the molecular basis of how HLA-II antigen presentation is involved in disease progression and treatment, systematic HLA-II peptidomics combined with multiomic analyses of diverse cell types in healthy and diseased states is required. For this reason, MS-based innovations that facilitate investigations into the interplay between disease pathologies and the presentation of HLA-II peptides to CD4+ T cells will aid in the development of patient-focused immunotherapies.","journal":"Molecular & Cellular Proteomics","year":2021,"id":174498,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9548,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":44968,"name":"Susan Klaeger","orcid":"0000-0002-0074-5163","position":1,"is_corresponding":false},{"id":2216,"name":"Karl R. Clauser","orcid":"0000-0002-1052-9456","position":2,"is_corresponding":false},{"id":44969,"name":"Siranush Sarkizova","orcid":"0000-0003-2530-8610","position":3,"is_corresponding":false},{"id":554216,"name":"Shira Weingarten-Gabbay","orcid":"0000-0001-7579-0236","position":4,"is_corresponding":false},{"id":6340,"name":"Daniel B. Graham","orcid":"0000-0002-8403-8115","position":5,"is_corresponding":false},{"id":2226,"name":"Steven A. Carr","orcid":"0000-0002-7203-4299","position":6,"is_corresponding":false},{"id":554219,"name":"Jennifer G. Abelin","orcid":"0000-0001-5262-7241","position":7,"is_corresponding":false},{"id":371257,"name":"Hannah B. Taylor","orcid":"0000-0003-2146-8764","position":0,"is_corresponding":true}],"reference_count":149,"raw_metadata":null,"created_at":"2026-07-18T23:47:06.584146Z","pmid":"34146720","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}