{"doi":"10.1016/j.mcpdig.2025.100227","title":"A Model for Rapid Innovation for Engagement, Enrollment, and Data and Sample Collection in a Diverse Cohort Study: Insights from All of Us Participant Labs","abstract":"Objective To improve engagement and retention of a cohort that reflects the United States population within the All of Us Research Program, we created and implemented an innovation infrastructure and initiatives. Participants and Methods All of Us Participant Labs (APL) established innovation-specific processes to rapidly ideate, select, implement, and evaluate cost-effective innovative initiatives, while mitigating risks. This was done within four priority areas: accelerating enrollment, enhancing engagement and retention, improving biospecimen collection, and broadening data types. Participants within the All of Us Research Program were engaged in this research between April 2022 and May 2024. Results We present a summary of APL processes and portfolio along with five specific initiatives that rapidly tested innovative ways to increase task completion and broaden biospecimen submission accessibility. Each initiative's cost-benefit profile was evaluated by a committee of program leadership. Findings include: 1) offering compensation increased task completion, the degree of which was dependent on the context and amount of compensation; 2) adding evening and weekend blood donation appointment times and distributing saliva collection kits through community partners increased donations from participants who have been historically underrepresented in biomedical research (UBR). On average, program staff predicted initiative effect sizes would be more than double their actual effect. Conclusion We demonstrated that large research studies can rapidly innovate to meet program goals, including a focus on diversity. We identified specific strategies and tactics to improve health research engagement and retention, with a focus on UBR communities, that can be utilized by numerous health research studies.","journal":"Mayo Clinic Proceedings Digital Health","year":2025,"id":544317,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.781,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1434533,"name":"Jessica Chen","orcid":"0000-0002-3919-0230","position":1,"is_corresponding":false},{"id":1316956,"name":"Romina Foster-Bonds","orcid":null,"position":2,"is_corresponding":false},{"id":1316955,"name":"Andrea Goosen","orcid":null,"position":3,"is_corresponding":false},{"id":1415054,"name":"Gayle Valensky","orcid":null,"position":4,"is_corresponding":false},{"id":1313626,"name":"Ethan Dinh-Luong","orcid":null,"position":5,"is_corresponding":false},{"id":444722,"name":"Rachele Peterson","orcid":null,"position":6,"is_corresponding":false},{"id":6434,"name":"Geoffrey S. Ginsburg","orcid":"0000-0003-4739-9808","position":7,"is_corresponding":false},{"id":555879,"name":"Chris Lunt","orcid":"0000-0002-8504-0735","position":8,"is_corresponding":false},{"id":227521,"name":"Vik Kheterpal","orcid":"0000-0002-4752-4229","position":9,"is_corresponding":false},{"id":33022,"name":"Eric J. Topol","orcid":"0000-0002-1478-4729","position":10,"is_corresponding":false},{"id":234347,"name":"Allison Mandich","orcid":null,"position":11,"is_corresponding":false},{"id":1434905,"name":"Yentram Huyen","orcid":null,"position":12,"is_corresponding":false},{"id":721807,"name":"Julia Moore Vogel","orcid":"0000-0002-4902-3540","position":13,"is_corresponding":false},{"id":1237402,"name":"Janna Ter Meer","orcid":null,"position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":null,"created_at":"2026-07-19T02:53:12.864581Z","pmid":"40548175","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}