{"doi":"10.1016/j.mce.2003.10.011","title":"The regulation of aldosterone synthase expression","abstract":null,"journal":"Molecular and Cellular Endocrinology","year":2004,"id":632086,"datarank":8.526246023793574,"base_score":5.375278407684165,"endowment":5.375278407684165,"self_citation_contribution":0.8062917611526249,"citation_network_contribution":7.719954262640949,"self_endowment_contribution":0.8062917611526249,"citer_contribution":7.719954262640949,"corpus_percentile":null,"corpus_rank":null,"citation_count":215,"citer_count":195,"citers_with_citation_signal":170,"citers_with_endowment":170,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1638346,"name":"Perrin C White","orcid":null,"position":1,"is_corresponding":false},{"id":1585028,"name":"William E Rainey","orcid":null,"position":2,"is_corresponding":false},{"id":1638344,"name":"Mary H Bassett","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The regulation of aldosterone synthase expression","abstract":"Aldosterone, the primary human mineralocorticoid, is a major regulator of intravascular volume and blood pressure. The capacity of the adrenal gland to produce aldosterone is controlled, in large part, by the regulated transcription of CYP11B2, the gene encoding aldosterone synthase. Aldosterone synthase is responsible for the conversion of 11-deoxycorticosterone to aldosterone and is expressed only within the zona glomerulosa of the adrenal cortex. The development of new systems for in vitro studies of expression has helped define molecular mechanisms that regulate this enzyme and thus the capacity of the adrenal gland to produce aldosterone. Both potassium and angiotensin II (ANG II) increase intracellular calcium levels, which regulate expression of CYP11B2 through transcription factors that interact with defined sites in the 5'-flanking region of the gene.","is_dataset_classified":null,"base_score":5.375278407684165,"endowment":5.375278407684165,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15134803","pmcid":null,"openalex_id":"https://openalex.org/W2124108262","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"DK 37867","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"DK 54408","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"DK 43140","title":null}],"total_grants":3,"fwci":2.9432,"citation_percentile":0.91724771,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":8},{"year":2014,"count":13},{"year":2015,"count":8},{"year":2016,"count":19},{"year":2017,"count":14},{"year":2018,"count":6},{"year":2019,"count":7},{"year":2020,"count":6},{"year":2021,"count":11},{"year":2022,"count":8},{"year":2023,"count":13},{"year":2024,"count":9},{"year":2025,"count":12},{"year":2026,"count":4}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0303720703003824?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0303720703003824?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.mce.2003.10.011","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15134803","host_type":"repository"}],"fields_of_study":["Hormonal Regulation and Hypertension","Estrogen and related hormone effects","Cardiovascular, Neuropeptides, and Oxidative Stress Research","Adrenal Glands","Aldosterone","Angiotensin II","Cytochrome P-450 CYP11B2","Gene Expression Regulation, Enzymologic","Humans","Potassium","Steroid 11-beta-Hydroxylase","Transcription Factors","Transcription, Genetic","Transcriptional Activation"],"mesh_terms":["Adrenal Glands","Aldosterone","Angiotensin II","Humans","Potassium","Steroid 11-beta-Hydroxylase","Transcription Factors","Transcription, Genetic","Transcriptional Activation","Gene Expression Regulation, Enzymologic","Cytochrome P-450 CYP11B2"],"keywords":["Aldosterone synthase","Zona glomerulosa","Aldosterone","Mineralocorticoid","Internal medicine","Steroid 11-beta-hydroxylase","Endocrinology","Adrenal cortex","Biology","Adrenal gland","Angiotensin II","Mineralocorticoid receptor","Renin–angiotensin system","Cell biology","Blood pressure","Medicine","Steroid","Hormone"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T01:43:30.998569Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}