{"doi":"10.1016/j.mayocp.2023.09.016","title":"Trends of Lipid Concentrations, Awareness, Evaluation, and Treatment in Severe Dyslipidemia in US Adults","abstract":null,"journal":"Mayo Clinic Proceedings","year":2024,"id":629178,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":51211,"name":"Mokshad Gaonkar","orcid":"0000-0003-0309-6813","position":1,"is_corresponding":false},{"id":51214,"name":"Nirav Patel","orcid":null,"position":2,"is_corresponding":false},{"id":7140,"name":"Joshua W. Knowles","orcid":"0000-0003-1922-7240","position":3,"is_corresponding":false},{"id":1390100,"name":"Pradeep Natarajan","orcid":"0009-0005-9754-1376","position":4,"is_corresponding":false},{"id":51221,"name":"Garima Arora","orcid":"0000-0001-6402-6910","position":5,"is_corresponding":false},{"id":51222,"name":"Pankaj Arora","orcid":"0000-0003-2420-3550","position":6,"is_corresponding":false},{"id":51209,"name":"Naman S. Shetty","orcid":"0000-0003-3600-126X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Trends of Lipid Concentrations, Awareness, Evaluation, and Treatment in Severe Dyslipidemia in US Adults","abstract":"<h4>Objective</h4>To evaluate the contemporary trends of lipid concentrations, cholesterol evaluation, hypercholesterolemia awareness, and statin use among individuals with severe dyslipidemia (low-density lipoprotein cholesterol [LDL-C] level ≥190 mg/dL) between 2011 and 2020.<h4>Patients and methods</h4>This serial cross-sectional analysis included nonpregnant adults ≥20 years of age from the National Health and Nutrition Examination Survey between 2011 and 2020. Age-adjusted weighted trends of LDL-C, triglycerides, cholesterol evaluation in the past 5 years, hypercholesterolemia awareness, and documented statin use among individuals with severe dyslipidemia were estimated.<h4>Results</h4>Among 24,722 participants included, the prevalence of severe dyslipidemia was 5.4% (SE: 0.2%) which was stable across the study period (P<sub>trend</sub>=.78). Among individuals with severe dyslipidemia (mean age: 55.3 [SE: 0.7] years; 52.2% females; 68.8% non-Hispanic White), LDL-C (224.3 [SE: 4.2] mg/dL in 2011-2012 to 224.2 [SE: 4.6] mg/dL in 2017-2020; P<sub>trend</sub> =.83), and triglyceride (123.3 [SE: 1.1] mg/dL in 2011-2012 to 101.8 [SE: 1.1] mg/dL in 2017-2020; P<sub>trend</sub>=.13), levels remained stable from 2011 to 2020. The rates of cholesterol evaluation in the past 5 years (72.0% [SE: 5.7%] in 2011-2012 to 78.0% [SE: 4.8%] in 2017-2020; P<sub>trend</sub>=.91), hypercholesterolemia awareness (48.1% [SE: 5.5%] in 2011-2012 to 51.9% [SE: 5.8%] in 2017- 2020; P<sub>trend</sub>=.77), and documented statin use (34.7% [SE: 4.5%] in 2011-2012 to 33.4% [SE: 4.0%] in 2017-2020; P<sub>trend</sub>=.28) remained stagnant in individuals with severe dyslipidemia between 2011 and 2020.<h4>Conclusion</h4>Among individuals with severe dyslipidemia, cholesterol evaluation and hypercholesterolemia awareness rates were stable at ∼75% and ∼50% in the past decade. Only ∼34% of individuals with severe dyslipidemia took statins between 2011 and 2020, which likely contributed to the stable LDL-C levels noted across the study period. Further investigations into the determinants of statin use and adherence to statins are needed.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38189687","pmcid":"PMC10873035","openalex_id":null,"authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL163081","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"K23 HL146887","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK106236","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL160982","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK116074","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL163852","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK120565","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK056336","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK116750","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK107437","title":null}],"total_grants":10,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10873035/pdf/nihms-1935416.pdf","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0025619623004640?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0025619623004640?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Humans","Hypercholesterolemia","Cholesterol","Triglycerides","Hydroxymethylglutaryl-CoA Reductase Inhibitors","Nutrition Surveys","Cross-Sectional Studies","Adult","Middle Aged","Female","Male","Dyslipidemias","Cholesterol, LDL","Hyperlipidemias"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T17:19:22.738846Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}