{"doi":"10.1016/j.mayocp.2022.10.013","title":"Association of Initial and Longitudinal Changes in C-reactive Protein With the Risk of Cardiovascular Disease, Cancer, and Mortality","abstract":"OBJECTIVE: To evaluate the value of serial C-reactive protein (CRP) measurements in predicting the risk of cardiovascular disease (CVD), cancer, and mortality. METHODS: The analysis was performed using data from two prospective, population-based observational cohorts: the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study and the Framingham Heart Study (FHS). A total of 9253 participants had CRP measurements available at two examinations (PREVEND: 1997-1998 and 2001-2002; FHS Offspring cohort: 1995-1998 and 1998-2001). All CRP measurements were natural log-transformed before analyses. Cardiovascular disease included fatal and nonfatal cardiovascular, cerebrovascular and peripheral vascular events, and heart failure. Cancer included all malignancies except nonmelanoma skin cancers. RESULTS: <.001 in the multivariable model). Baseline CRP, as well as increase in CRP over time (ΔCRP), were associated with incident CVD (hazard ratio [HR]: 1.29 per 1-SD increase; 95% confidence interval [CI]: 1.29 to 1.47, and HR per 1-SD increase: 1.19; 95% CI: 1.09 to 1.29 respectively). Similar findings were observed for incident cancer (baseline CRP, HR: 1.17; 95% CI: 1.09 to 1.26; ΔCRP, HR: 1.08; 95% CI: 1.01 to 1.15) and mortality (baseline CRP, HR: 1.29; 95% CI: 1.21 to 1.37; ΔCRP, HR: 1.10; 95% CI: 1.05 to 1.16). CONCLUSION: Initial as well as subsequent increases in CRP levels predict future CVD, cancer, and mortality in the general population.","journal":"Mayo Clinic Proceedings","year":2023,"id":322142,"datarank":0.5606504427425053,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":0.0,"self_endowment_contribution":0.5606504427425053,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8196,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":865952,"name":"Dongyu Wang","orcid":"0000-0002-1317-2739","position":1,"is_corresponding":false},{"id":648410,"name":"Joseph Pierre Aboumsallem","orcid":"0000-0001-8186-6620","position":2,"is_corresponding":false},{"id":1035524,"name":"Canxia Shi","orcid":"0000-0002-0006-2012","position":3,"is_corresponding":false},{"id":1035525,"name":"Sanne de Wit","orcid":"0000-0002-9266-0430","position":4,"is_corresponding":false},{"id":457211,"name":"Elizabeth Liu","orcid":"0000-0002-6031-3047","position":5,"is_corresponding":false},{"id":900,"name":"Emily S. Lau","orcid":"0000-0001-9361-6397","position":6,"is_corresponding":false},{"id":21853,"name":"Stephan J. L. Bakker","orcid":"0000-0003-3356-6791","position":7,"is_corresponding":false},{"id":21877,"name":"Ron T. Gansevoort","orcid":"0000-0002-3223-0906","position":8,"is_corresponding":false},{"id":941366,"name":"Bert van der Vegt","orcid":"0000-0002-2613-1506","position":9,"is_corresponding":false},{"id":672851,"name":"Manol Jovani","orcid":"0000-0001-6803-8521","position":10,"is_corresponding":false},{"id":695822,"name":"Bernard E. Kreger","orcid":null,"position":11,"is_corresponding":false},{"id":695823,"name":"Greta Lee Splansky","orcid":null,"position":12,"is_corresponding":false},{"id":1034,"name":"Emelia J. Benjamin","orcid":"0000-0003-4076-2336","position":13,"is_corresponding":false},{"id":24661,"name":"Ramachandran S. Vasan","orcid":"0000-0001-7357-5970","position":14,"is_corresponding":false},{"id":230820,"name":"Martin G. Larson","orcid":"0000-0002-9631-1254","position":15,"is_corresponding":false},{"id":38114,"name":"Daniel Levy","orcid":"0000-0003-1843-8724","position":16,"is_corresponding":false},{"id":892,"name":"Jennifer E. Ho","orcid":"0000-0002-7987-4768","position":17,"is_corresponding":false},{"id":55735,"name":"Rudolf A. de Boer","orcid":"0000-0002-4775-9140","position":18,"is_corresponding":false},{"id":278978,"name":"Navin Suthahar","orcid":"0000-0002-7781-2897","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:07:42.497873Z","pmid":"37019514","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}