{"doi":"10.1016/j.maturitas.2026.108886","title":"Development of cardiovascular risk factors in women with a BRCA1/2 pathogenic variant within five years after tubo-ovarian cancer risk reduction in the TUBA study","abstract":null,"journal":"Maturitas","year":2026,"id":628936,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1628656,"name":"Marleen M.H.J. van Gelder","orcid":null,"position":1,"is_corresponding":false},{"id":1628657,"name":"Rosella P.M.G. Hermens","orcid":null,"position":2,"is_corresponding":false},{"id":1628658,"name":"Majke H.D. van Bommel","orcid":null,"position":3,"is_corresponding":false},{"id":1628659,"name":"Mirjam J.A. Apperloo","orcid":null,"position":4,"is_corresponding":false},{"id":1628660,"name":"Marieke Arts-de Jong","orcid":null,"position":5,"is_corresponding":false},{"id":1040257,"name":"Monique M.A. Brood-van Zanten","orcid":"0000-0002-2275-9558","position":6,"is_corresponding":false},{"id":1628661,"name":"Sjors F.P.J. Coppus","orcid":null,"position":7,"is_corresponding":false},{"id":1628662,"name":"Jose Custers","orcid":null,"position":8,"is_corresponding":false},{"id":1628664,"name":"Helena C. van Doorn","orcid":null,"position":9,"is_corresponding":false},{"id":15038,"name":"Katja N. Gaarenstroom","orcid":"0000-0002-4702-1680","position":10,"is_corresponding":false},{"id":1628666,"name":"Marline G. Harmsen","orcid":null,"position":11,"is_corresponding":false},{"id":1628667,"name":"Marjan Knippenberg","orcid":null,"position":12,"is_corresponding":false},{"id":686821,"name":"Luc R.C.W. van Lonkhuijzen","orcid":"0000-0001-6905-2704","position":13,"is_corresponding":false},{"id":1628668,"name":"Jurgen M.J. Piek","orcid":null,"position":14,"is_corresponding":false},{"id":1628669,"name":"Michiel Simons","orcid":null,"position":15,"is_corresponding":false},{"id":1628670,"name":"Brigitte F.M. Slangen","orcid":null,"position":16,"is_corresponding":false},{"id":1628671,"name":"Rachel Tros","orcid":null,"position":17,"is_corresponding":false},{"id":1628672,"name":"M. Caroline Vos","orcid":null,"position":18,"is_corresponding":false},{"id":1628673,"name":"Refika Yigit","orcid":"0000-0001-7379-2203","position":19,"is_corresponding":false},{"id":1628674,"name":"Ronald P. Zweemer","orcid":null,"position":20,"is_corresponding":false},{"id":633609,"name":"Nicoline Hoogerbrugge","orcid":null,"position":21,"is_corresponding":false},{"id":1628677,"name":"C. Marleen Kets","orcid":null,"position":22,"is_corresponding":false},{"id":1628679,"name":"Angela H.E.M. Maas","orcid":null,"position":23,"is_corresponding":false},{"id":1628680,"name":"Miranda P. Steenbeek","orcid":null,"position":24,"is_corresponding":false},{"id":1040255,"name":"Joanne A. de Hullu","orcid":"0000-0001-5578-092X","position":25,"is_corresponding":false},{"id":1628654,"name":"Tamar A. Gootzen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Development of cardiovascular risk factors in women with a BRCA1/2 pathogenic variant within five years after tubo-ovarian cancer risk reduction in the TUBA study","abstract":"OBJECTIVES: The effects of risk-reducing salpingo-oophorectomy on the development of cardiovascular risk factors in women with BRCA1/2 pathogenic variants are unknown. We compared the development of cardiovascular risk factors 5 years post-surgery between participants who had risk-reducing salpingo-oophorectomy with and without hormonal replacement therapy and participants who had risk-reducing salpingectomy. STUDY DESIGN: Eligible participants with a BRCA1/2 pathogenic variant from the TUBA study were longitudinally followed and categorized into three groups: (1) salpingectomy without subsequent oophorectomy within 5 years, (2) salpingo-oophorectomy with hormonal replacement therapy (use ≥3 years), (3) salpingo-oophorectomy without hormonal replacement therapy (use <3 years). MAIN OUTCOME MEASURES: Development of cardiovascular risk factors between baseline and 5 years after salpingo-oophorectomy or salpingectomy. RESULTS: Of the 400 participants, 258 (64.5%) had salpingectomy, 93 (23.3%) had salpingo-oophorectomy and used hormonal replacement therapy ≥3 years, and 49 (12.2%) used it for <3 years. At 5-year follow-up, the cardiovascular risk factor hypercholesterolemia (increased LDLc) was observed more often after salpingo-oophorectomy with (18.8%, p ≤0.001) and without (17.1%, p = 0.03) hormonal replacement therapy compared with the salpingectomy group (5.7%). Larger proportions of participants after salpingo-oophorectomy with (47.1%) and without (50.0%) hormonal replacement therapy experienced an increase in the number of risk factors present compared with participants after salpingectomy (24.5%; p = 0.009, p = 0.02, respectively). CONCLUSIONS: Overall, only a small proportion of the study population developed cardiovascular risk factors within five years after salpingo-oophorectomy. However, participants developed the risk factor hypercholesterolemia more after salpingo-oophorectomy (irrespective of use of hormonal replacement therapy) compared with after salpingectomy. TRIAL REGISTRATION: NCT02321228.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41730824","pmcid":null,"openalex_id":"https://openalex.org/W7130936891","authors":[],"funders":[{"funder_name":"Dutch Cancer Society","grant_id":"KUN2014\\u20137187","title":null}],"total_grants":1,"fwci":6.8158,"citation_percentile":0.94145817,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://www.maturitas.org/article/S0378-5122(26)00063-0/pdf","host_type":"journal"},{"url":"https://www.maturitas.org/article/S0378-5122(26)00063-0/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0378512226000630?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0378512226000630?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.maturitas.2026.108886","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41730824","host_type":"repository"},{"url":"https://cris.maastrichtuniversity.nl/en/publications/1ca58459-1086-4418-832f-a85523cd35ca","host_type":"repository"},{"url":"https://research.rug.nl/en/publications/b6a20a2d-bdb2-4d43-93dd-48aefc9c1220","host_type":"repository"},{"url":"https://dspace.library.uu.nl/handle/1874/469498","host_type":"repository"},{"url":"https://hdl.handle.net/2066/330170","host_type":"repository"}],"fields_of_study":["BRCA gene mutations in cancer","Cancer Risks and Factors","Ovarian cancer diagnosis and treatment","Adult","Female","Humans","Middle Aged","BRCA1 Protein","BRCA2 Protein","Cardiovascular Diseases","Fallopian Tube Neoplasms","Heart Disease Risk Factors","Hormone Replacement Therapy","Longitudinal Studies","Ovarian Neoplasms","Ovariectomy","Risk Factors","Salpingectomy","Salpingo-oophorectomy"],"mesh_terms":["Salpingo-oophorectomy","Heart Disease Risk Factors","Adult","Cardiovascular Diseases","Fallopian Tube Neoplasms","Female","Humans","Longitudinal Studies","Middle Aged","Ovarian Neoplasms","Ovariectomy","Risk Factors","Estrogen Replacement Therapy","BRCA1 Protein","Hormone Replacement Therapy","Genes, BRCA2","BRCA2 Protein","Salpingectomy"],"keywords":["Reduction (mathematics)","Cancer","Risk factor","Risk assessment","Ovarian cancer","Prevention","BRCA1","BRCA2","Cardiovascular Risk","Hormonal Replacement Therapy"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T15:38:33.854337Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}