{"doi":"10.1016/j.matbio.2024.10.006","title":"Fibroblast integrin α11β1 is a collagen assembly receptor in mechanoregulated fibrillar adhesions","abstract":"Solid epithelial cancers with significant desmoplasia are characterized by an excessive deposition of collagen-based matrix, which often supports tumor progression. However, the mechanism of how collagen receptors mediate collagen fibrillogenesis still remains mostly unclear. We show that the collagen-binding integrin α11β1 can co-localize with tensin-1 and deposited collagen I in human pancreatic ductal adenocarcinoma (PDAC) stroma. In addition to the canonical fibrillar adhesion integrin α5β1 expressed by human PDAC cancer-associated fibroblasts (CAFs), tensin-1-positive fibrillar adhesions contained α11β1 but lacked α1β1 and α2β1. CAFs lacking α5β1 expression displayed mechanoregulated and tensin-1 dependent α11β1 fibrillar adhesions, suggesting independent roles of the two integrins with regards to fibrillar adhesions-based de novo fibrillogenesis. Further, we demonstrate that cell surface-associated collagen I assembly necessitated α11β1, but not α5β1 expression. In summary, α11β1 integrin is a novel component of fibrillar adhesions, which is strategically positioned to mediate de novo collagen fibrillogenesis at the cell surface under pro-fibrotic conditions.","journal":"Matrix Biology","year":2024,"id":439186,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1249806,"name":"Pugazendhi M Erusappan","orcid":"0000-0001-8360-1167","position":1,"is_corresponding":false},{"id":103959,"name":"Edna Cukierman","orcid":"0000-0002-1452-9576","position":2,"is_corresponding":false},{"id":1249807,"name":"Joan Chang","orcid":"0000-0002-7283-9759","position":3,"is_corresponding":false},{"id":240406,"name":"Anders Molven","orcid":"0000-0003-1847-3079","position":4,"is_corresponding":false},{"id":1249808,"name":"Uwe Hansen","orcid":"0000-0001-8519-8228","position":5,"is_corresponding":false},{"id":219678,"name":"Cédric Zeltz","orcid":"0000-0002-7828-6868","position":6,"is_corresponding":false},{"id":1211909,"name":"Donald Gullberg","orcid":"0000-0002-7245-4437","position":7,"is_corresponding":false},{"id":1249805,"name":"Moses Musiime","orcid":"0000-0002-8336-7021","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-19T02:00:47.992543Z","pmid":"39406317","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}