{"doi":"10.1016/j.matbio.2013.12.001","title":"Heparan sulfate 3-O-sulfation: A rare modification in search of a function","abstract":null,"journal":"Matrix Biology","year":2014,"id":606899,"datarank":0.8117469077782561,"base_score":5.4116460518550396,"endowment":5.4116460518550396,"self_citation_contribution":0.8117469077782561,"citation_network_contribution":0.0,"self_endowment_contribution":0.8117469077782561,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":223,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":594589,"name":"Ding Xu","orcid":"0000-0002-7634-4315","position":1,"is_corresponding":false},{"id":779401,"name":"Roger Lawrence","orcid":"0000-0002-5027-2579","position":2,"is_corresponding":false},{"id":106562,"name":"Jeffrey D. Esko","orcid":"0000-0001-8322-1834","position":3,"is_corresponding":false},{"id":106542,"name":"Bryan E. Thacker","orcid":"0000-0003-0517-0810","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Heparan sulfate 3-O-sulfation: A rare modification in search of a function","abstract":"Many protein ligands bind to heparan sulfate, which results in their presentation, protection, oligomerization or conformational activation. Binding depends on the pattern of sulfation and arrangement of uronic acid epimers along the chains. Sulfation at the C3 position of glucosamine is a relatively rare, yet biologically significant modification, initially described as a key determinant for binding and activation of antithrombin and later for infection by type I herpes simplex virus. In mammals, a family of seven heparan sulfate 3-O-sulfotransferases installs sulfate groups at this position and constitutes the largest group of sulfotransferases involved in heparan sulfate formation. However, to date very few proteins or biological systems have been described that are influenced by 3-O-sulfation. This review describes our current understanding of the prevalence and structure of 3-O-sulfation sites, expression and substrate specificity of the 3-O-sulfotransferase family and the emerging roles of 3-O-sulfation in biology.","is_dataset_classified":null,"base_score":5.4116460518550396,"endowment":5.4116460518550396,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24361527","pmcid":"PMC4039620","openalex_id":"https://openalex.org/W2001101255","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"P01 HL107150","title":null},{"funder_name":"NCI NIH HHS","grant_id":"T32 CA067754","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R21 HL098910","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL107150","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM093131","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM93131","title":null},{"funder_name":"National Institutes of Health","grant_id":"5T32CA067754-25","title":"Cancer Biology, Informatics & Omics (CBIO) Training Program"}],"total_grants":7,"fwci":6.8605,"citation_percentile":0.9771436,"influential_citations":0,"citation_trend":[{"year":2014,"count":10},{"year":2015,"count":17},{"year":2016,"count":18},{"year":2017,"count":9},{"year":2018,"count":17},{"year":2019,"count":11},{"year":2020,"count":24},{"year":2021,"count":31},{"year":2022,"count":26},{"year":2023,"count":14},{"year":2024,"count":22},{"year":2025,"count":14},{"year":2026,"count":10}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.matbio.2013.12.001","host_type":"journal"},{"url":"https://doi.org/10.1016/j.matbio.2013.12.001","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0945053X13001698?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0945053X13001698?httpAccept=text/xml","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24361527","host_type":"repository"},{"url":"https://escholarship.org/uc/item/7741f7p0","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4039620","host_type":"repository"},{"url":"http://www.escholarship.org/uc/item/7741f7p0","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.matbio.2013.12.001","host_type":""},{"url":"https://dx.doi.org/10.1016/j.matbio.2013.12.001","host_type":""}],"fields_of_study":["Proteoglycans and glycosaminoglycans research","Glycosylation and Glycoproteins Research","Carbohydrate Chemistry and Synthesis","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Antithrombins","Binding Sites","Cyclophilins","Evolution, Molecular","Heparan Sulfate","Humans","Models, Molecular","Molecular Structure","Oligosaccharides","Phylogeny","Species Specificity","Sulfates","Sulfotransferases","Uronic Acids","Viral Envelope Proteins"],"mesh_terms":["Animals","Antithrombins","Binding Sites","Heparan Sulfate","Heparitin Sulfate","Humans","Models, Molecular","Oligosaccharides","Phylogeny","Species Specificity","Sulfates","Uronic Acids","Viral Envelope Proteins","Sulfotransferases","Molecular Structure","Evolution, Molecular","Cyclophilins"],"keywords":["Sulfation","Heparan sulfate","Chemistry","Biochemistry","Sulfotransferase","Sulfate","Uronic acid","Perlecan","Glucosamine","Glycosaminoglycan","Stereochemistry","Polysaccharide","Organic chemistry","antithrombin","growth factors","3-O-sulfotransferases","Models, Molecular","Binding Sites","Molecular Structure","Sulfates","Oligosaccharides","Antithrombins","Evolution, Molecular","Cyclophilins","Uronic Acids","Species Specificity","Viral Envelope Proteins","Animals","Humans","Sulfotransferases","Molecular Biology","Phylogeny"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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