{"doi":"10.1016/j.mam.2017.02.003","title":"Specialized pro-resolving mediators in cardiovascular diseases","abstract":null,"journal":"Molecular Aspects of Medicine","year":2017,"id":595864,"datarank":0.6862066467755076,"base_score":4.574710978503383,"endowment":4.574710978503383,"self_citation_contribution":0.6862066467755076,"citation_network_contribution":0.0,"self_endowment_contribution":0.6862066467755076,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":96,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":677052,"name":"Matthew Spite","orcid":"0000-0002-8868-3648","position":1,"is_corresponding":false},{"id":663915,"name":"Gabrielle Fredman","orcid":"0000-0001-9974-0962","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Specialized pro-resolving mediators in cardiovascular diseases","abstract":"The resolution of inflammation is a highly regulated process enacted by endogenous mediators including specialized pro-resolving lipid mediators (SPMs): the lipoxins, resolvins, protectins and maresins. SPMs activate specific cellular receptors to temper the production of pro-inflammatory mediators, diminish the recruitment of neutrophils, and promote the clearance of dead cells by macrophages. These mediators also enhance host-defense and couple resolution of inflammation to subsequent phases of tissue repair. Given that unresolved inflammation plays a causal role in the development of cardiovascular diseases, an understanding of these endogenous pro-resolving processes is critical for determining why cardiovascular inflammation does not resolve. Here, we discuss the receptor-dependent actions of resolvins and related pro-resolving mediators and highlight their emerging roles in the cardiovascular system. We propose that stimulating resolution could be a novel approach for treating chronic cardiovascular inflammation without promoting immunosuppression.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28257820","pmcid":"PMC5716486","openalex_id":null,"authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"R00 HL119587","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL106173","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"K99 HL119587","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"P01 GM095467","title":null}],"total_grants":4,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5716486","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0098299717300171?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0098299717300171?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":["Animals","Atherosclerosis","Cardiovascular Diseases","Humans","Inflammation Mediators","Ischemia","Myocardial Infarction","Peptides","Platelet Activation","Thrombosis"],"mesh_terms":["Animals","Humans","Cardiovascular Diseases","Myocardial Infarction","Thrombosis","Ischemia","Peptides","Inflammation Mediators","Platelet Activation","Atherosclerosis"],"keywords":["Atherosclerosis","Resolution Of Inflammation","Specialized Pro-resolving Mediators"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T17:58:37.839678Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}