{"doi":"10.1016/j.mad.2011.04.007","title":"Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence","abstract":null,"journal":"Mechanisms of Ageing and Development","year":2011,"id":652957,"datarank":0.5533319181170905,"base_score":3.6888794541139363,"endowment":3.6888794541139363,"self_citation_contribution":0.5533319181170905,"citation_network_contribution":0.0,"self_endowment_contribution":0.5533319181170905,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1703580,"name":"Krisztian Kvell","orcid":null,"position":1,"is_corresponding":false},{"id":1703582,"name":"Gergely Talabér","orcid":null,"position":2,"is_corresponding":false},{"id":1703584,"name":"Gyorgy Miskei","orcid":null,"position":3,"is_corresponding":false},{"id":1703585,"name":"Veronika Csongei","orcid":null,"position":4,"is_corresponding":false},{"id":1703586,"name":"Domokos Bartis","orcid":null,"position":5,"is_corresponding":false},{"id":314997,"name":"Graham Anderson","orcid":"0000-0002-2917-4085","position":6,"is_corresponding":false},{"id":1703587,"name":"Eric J. Jenkinson","orcid":null,"position":7,"is_corresponding":false},{"id":1703588,"name":"Judit E. Pongracz","orcid":null,"position":8,"is_corresponding":false},{"id":1703578,"name":"Zoltan Varecza","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence","abstract":"Members of the Wnt family of secreted glyco-lipo-proteins affect intrathymic T-cell development and are abundantly secreted by thymic epithelial cells (TECs) that create the specific microenvironment for thymocytes to develop into mature T-cells. During ageing, Wnt expression declines allowing adipoid involution of the thymic epithelium leading to reduced naïve T-cell output. The protein kinase C (PKC) family of serine-threonine kinases is involved in numerous intracellular biochemical processes, including Wnt signal transduction. In the present study, PKCδ expression is shown to increase with age and to co-localise with Wnt receptors Frizzled (Fz)-4 and -6. It is also demonstrated that connective tissue growth factor (CTGF) is a Wnt-4 target gene and is potentially involved in a negative feed-back loop of Wnt signal regulation. Down-regulation of Wnt-4 expression and activation of multiple repressor pathways suppressing β-catenin dependent signalling in TECs contribute to the initiation of thymic senescence.","is_dataset_classified":null,"base_score":3.6888794541139363,"endowment":3.6888794541139363,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21549744","pmcid":"PMC3146701","openalex_id":"https://openalex.org/W2014045732","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"079415","title":"Investigation of the role of Protein Kinase C (PKC) isoenzymes in the non-canonical Wnt signalling pathway during thymic epithelial cell developmentand differentiation"},{"funder_name":"Medical Research Council","grant_id":"G0401620","title":null},{"funder_name":"Wellcome Trust","grant_id":"","title":null},{"funder_name":"Wellcome Trust","grant_id":"","title":null}],"total_grants":4,"fwci":1.0952,"citation_percentile":0.75270744,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":4},{"year":2014,"count":4},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2017,"count":3},{"year":2018,"count":1},{"year":2019,"count":4},{"year":2020,"count":2},{"year":2021,"count":5},{"year":2022,"count":5},{"year":2023,"count":2},{"year":2024,"count":3},{"year":2025,"count":2}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0047637411000522/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0047637411000522/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0047637411000522?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0047637411000522?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.mad.2011.04.007","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21549744","host_type":"repository"},{"url":"http://real.mtak.hu/166310/1/2011_Mech_Age_Dev.pdf","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3146701","host_type":"repository"},{"url":"https://research.birmingham.ac.uk/portal/en/publications/multiple-suppression-pathways-of-canonical-wnt-signalling-control-thymic-epithelial-senescence(c5bb5ff5-0212-48ce-80e4-fc442d81af62).html","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3146701","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1016/j.mad.2011.04.007","host_type":""},{"url":"https://dx.doi.org/10.1016/j.mad.2011.04.007","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.mad.2011.04.007","host_type":""}],"fields_of_study":["Wnt/β-catenin signaling in development and cancer","Connective Tissue Growth Factor Research","Cancer-related gene regulation","0301 basic medicine","03 medical and health sciences","Animals","Cell Line","Cellular Senescence","Epithelial Cells","Frizzled Receptors","Gene Expression Regulation, Enzymologic","Humans","Mice","Mice, Inbred BALB C","Protein Kinase C-delta","Receptors, G-Protein-Coupled","Signal Transduction","T-Lymphocytes","Thymus Gland","Wnt Proteins","beta Catenin"],"mesh_terms":["Animals","Cell Line","Epithelial Cells","Humans","Mice, Inbred BALB C","T-Lymphocytes","Thymus Gland","Signal Transduction","Gene Expression Regulation, Enzymologic","Cellular Senescence","Receptors, G-Protein-Coupled","Wnt Proteins","Frizzled Receptors","beta Catenin","Mice","Protein Kinase C-delta"],"keywords":["Wnt signaling pathway","Cell biology","Biology","LRP6","Frizzled","Signal transduction","LRP5","Senescence","Protein kinase C","Kinase","Mice, Inbred BALB C","T-Lymphocytes","Epithelial Cells","Thymus Gland","Article","Frizzled Receptors","Gene Expression Regulation, Enzymologic","Cell Line","Receptors, G-Protein-Coupled","Wnt Proteins","Ageing","Mice","Protein Kinase C-delta","Animals","Humans","QR180 Immunology / immunológia","Cellular Senescence","beta Catenin","Developmental Biology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"refseq"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T17:37:32.175714Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}