{"doi":"10.1016/j.lfs.2025.123559","title":"Type I interferon protects against bone loss in periodontitis by mitigating an interleukin (IL)-17-neutrophil axis","abstract":"Type I interferons (IFNs-I), a group of pleiotropic cytokines, critically modulate host response in various inflammatory diseases. However, the role of the IFN-I pathway in periodontitis remains largely unknown. In this report, we describe that the IFN-β levels in the gingival crevicular fluid of human subjects were negatively associated with periodontitis and clinical gingival inflammation. Disruption of IFN-I signaling worsened alveolar bone resorption in a ligature-induced periodontitis murine model. Deficiency of the IFN-I pathway resulted in an exaggerated inflammatory response in myeloid cells and drastically increased the interleukin-17 (IL-17)-mediated neutrophil recruitment in the gingiva. We further identified that the myeloid lineage-specific IFN-I response was essential in safeguarding against periodontal inflammation by suppressing the IL-17-producing γδ T cells in gingiva. IFN-I signaling also directly repressed osteoclastogenesis in monocytes, which are precursor cells for osteoclasts. Therefore, our findings demonstrate that an integral myeloid-specific IFN-I pathway protects against bone loss by keeping the IL-17-neutrophil axis in check and directly inhibiting osteoclast formation in periodontitis.","journal":"Life Sciences","year":2025,"id":519207,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9521,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":713868,"name":"Qiong Ding","orcid":"0000-0002-0552-4079","position":1,"is_corresponding":false},{"id":1388120,"name":"Angela X. Wang","orcid":null,"position":2,"is_corresponding":false},{"id":267806,"name":"Maoxuan Lin","orcid":"0000-0001-5191-1857","position":3,"is_corresponding":false},{"id":292343,"name":"Ning Yu","orcid":"0000-0002-3046-4338","position":4,"is_corresponding":false},{"id":292344,"name":"Kevin Moss","orcid":"0000-0003-2332-1774","position":5,"is_corresponding":false},{"id":1388121,"name":"Megumi A Williamson","orcid":null,"position":6,"is_corresponding":false},{"id":1199479,"name":"Di Miao","orcid":"0009-0008-5381-9198","position":7,"is_corresponding":false},{"id":292342,"name":"Julie T. Marchesan","orcid":"0000-0003-0610-3193","position":8,"is_corresponding":false},{"id":292341,"name":"Erliang Zeng","orcid":"0000-0002-2891-6497","position":9,"is_corresponding":false},{"id":1387529,"name":"Wei Shi","orcid":"0009-0003-0208-6012","position":10,"is_corresponding":false},{"id":495435,"name":"Hongli Sun","orcid":"0000-0001-8398-3011","position":11,"is_corresponding":false},{"id":109672,"name":"Yu L. Lei","orcid":"0000-0002-9868-9824","position":12,"is_corresponding":false},{"id":292346,"name":"Shaoping Zhang","orcid":"0000-0003-3004-4023","position":13,"is_corresponding":false},{"id":293710,"name":"Jinmei Zhang","orcid":null,"position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":null,"created_at":"2026-07-19T02:49:18.751199Z","pmid":"40086745","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}