{"doi":"10.1016/j.lfs.2022.121064","title":"Creatine supplementation protects against diet-induced non-alcoholic fatty liver but exacerbates alcoholic fatty liver","abstract":null,"journal":"Life Sciences","year":2022,"id":597225,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1529986,"name":"Paola S. Cella","orcid":null,"position":1,"is_corresponding":false},{"id":1529987,"name":"Mayra T.J. Testa","orcid":null,"position":2,"is_corresponding":false},{"id":1529988,"name":"Phillipe B. Guirro","orcid":null,"position":3,"is_corresponding":false},{"id":1529989,"name":"Walison Augusto da Silva Brito","orcid":null,"position":4,"is_corresponding":false},{"id":1529990,"name":"Camila S. Padilha","orcid":null,"position":5,"is_corresponding":false},{"id":1529991,"name":"Alessandra L. Cecchini","orcid":null,"position":6,"is_corresponding":false},{"id":389037,"name":"Robin P. da Silva","orcid":"0000-0002-6820-5817","position":7,"is_corresponding":false},{"id":1529992,"name":"José Alberto R. Duarte","orcid":null,"position":8,"is_corresponding":false},{"id":413477,"name":"Rafael Deminice","orcid":"0000-0002-9246-1079","position":9,"is_corresponding":false},{"id":1529985,"name":"Poliana C. Marinello","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Creatine supplementation protects against diet-induced non-alcoholic fatty liver but exacerbates alcoholic fatty liver","abstract":"<h4>Aims</h4>This work investigated the effects of creatine supplementation on different pathways related to the pathogenesis of non-alcoholic fatty liver disease and alcoholic liver disease.<h4>Main methods</h4>To induce alcoholic liver disease, male Swiss mice were divided into three groups: control, ethanol and ethanol supplemented with creatine. To induce non-alcoholic fatty liver disease, mice were divided into three groups: control, high-fat diet and high-fat diet supplemented with creatine. Each group consisted of eight animals. In both cases, creatine monohydrate was added to the diets (1 %; weight/vol).<h4>Key findings</h4>Creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease progression, demonstrated by attenuated liver fat accumulation and liver damage. On the other hand, when combined with ethanol, creatine supplementation up-regulated key genes related to ethanol metabolism, oxidative stress, inflammation and lipid synthesis, and exacerbated ethanol-induced liver steatosis and damage, demonstrated by increased liver fat accumulation and histopathological score, as well as elevated oxidative damage markers and inflammatory mediators.<h4>Significance</h4>Our results clearly demonstrated creatine supplementation exerts different outcomes in relation to non-alcoholic fatty liver disease and alcoholic liver disease, namely it protects against high-fat diet-induced non-alcoholic fatty liver disease but exacerbates ethanol-induced alcoholic liver disease. The exacerbating effects of the creatine and ethanol combination appear to be related to oxidative stress and inflammation-mediated up-regulation of ethanol metabolism.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36220368","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Conselho Nacional de Desenvolvimento Científico e Tecnológico","grant_id":"315131/2018-4","title":null},{"funder_name":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","grant_id":"","title":null}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0024320522007640?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0024320522007640?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Liver","Animals","Mice","Fatty Liver, Alcoholic","Liver Diseases, Alcoholic","Inflammation","Ethanol","Creatine","Oxidative Stress","Dietary Supplements","Male","Diet, High-Fat","Non-alcoholic Fatty Liver Disease"],"keywords":["Oxidative stress","Inflammation","Fatty liver","Steatosis","Alcoholic Metabolism"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T12:40:33.746361Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}