{"doi":"10.1016/j.lfs.2021.119875","title":"Nephroprotective effect of apilarnil in lipopolysaccharide-induced sepsis through TLR4/NF-κB signaling pathway","abstract":null,"journal":"Life Sciences","year":2021,"id":591797,"datarank":0.9625067486767311,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"self_citation_contribution":0.5333022092234121,"citation_network_contribution":0.42920453945331904,"self_endowment_contribution":0.5333022092234121,"citer_contribution":0.42920453945331904,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":24,"citers_with_citation_signal":18,"citers_with_endowment":18,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1514245,"name":"Züleyha Doganyigit","orcid":"0000-0002-6980-3384","position":1,"is_corresponding":false},{"id":1514246,"name":"Aslı Okan","orcid":"0000-0001-8152-7338","position":2,"is_corresponding":false},{"id":1514248,"name":"Emin Kaymak","orcid":"0000-0002-3818-2693","position":3,"is_corresponding":false},{"id":1514249,"name":"Sibel Silici","orcid":null,"position":4,"is_corresponding":false},{"id":1514244,"name":"Nihal Inandiklioglu","orcid":"0000-0001-7137-3929","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Nephroprotective effect of apilarnil in lipopolysaccharide-induced sepsis through TLR4/NF-κB signaling pathway","abstract":"<h4>Aims</h4>In this study, we aimed to investigate the protective effect of apilarnil on kidney damage in the sepsis model induced by LPS.<h4>Main methods</h4>64 Sprague Dawley adult male rats were randomly divided into eight groups; control group, groups in which 0.2, 0.4 and 0.8 g/kg/bw apilarnil (API) was applied by oral gavage method for 10 days, LPS group in which 30 mg/kg/bw lipopolysaccharide (LPS) administered as intraperitoneally, groups in which LPS + 0.2, LPS+ 0.4 and LPS +0,8 API was applied. Six hour after the last administration the rats were anesthetized for euthanasia and kidney tissues were removed for RT-PCR analysis, immunohistochemical analysis and histopathologic analysis.<h4>Key finding</h4>According to the results of RT-PCR expression levels of IL-6, IL-1β, NF-κB, TNF-α and TLR4 were significantly reduced in the LPS + 0,8 API group. Immunoreactivity of TLR4, pNF-κB and TNF-α levels in the LPS + 0.8 apilarnil group were significantly lower than in the LPS and LPS + 0.2 apilarnil groups. Histologically, compared to the LPS group the glomerular damage score tended to decrease in the LPS + 0,4 API and LPS+ 0,8 API groups, while the tubulointerstitial injury score decreased especially in the LPS + 0,8 API group.<h4>Significance</h4>In the present study, 0,8 g/kg dose of apilarnil promoted potential renoprotective effects which were achieved, at least in part, by the modulation of important markers of the local immune response in the model of LPS-induced sepsis.","is_dataset_classified":null,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34384831","pmcid":null,"openalex_id":"https://openalex.org/W3192422131","authors":[],"funders":[{"funder_name":"Yozgat Bozok University","grant_id":"6602c-TF/19-285","title":null}],"total_grants":1,"fwci":1.2459,"citation_percentile":0.78440143,"influential_citations":0,"citation_trend":[{"year":2022,"count":4},{"year":2023,"count":6},{"year":2024,"count":7},{"year":2025,"count":9},{"year":2026,"count":8}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0024320521008626?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0024320521008626?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.lfs.2021.119875","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34384831","host_type":"repository"}],"fields_of_study":["Immune Response and Inflammation","Flavonoids in Medical Research","NF-κB Signaling Pathways","Animals","Biological Products","Gene Expression Regulation","Kidney","Lipopolysaccharides","Male","NF-kappa B","Protective Agents","Rats, Sprague-Dawley","Sepsis","Signal Transduction","Toll-Like Receptor 4","Rats"],"mesh_terms":["Animals","Biological Products","Gene Expression Regulation","Kidney","Lipopolysaccharides","Male","Signal Transduction","NF-kappa B","Rats, Sprague-Dawley","Sepsis","Protective Agents","Toll-Like Receptor 4","Rats"],"keywords":["TLR4","Lipopolysaccharide","Sepsis","Kidney","Tumor necrosis factor alpha","Pharmacology","Medicine","Immunohistochemistry","NF-κB","Inflammation","Immune system","Internal medicine","Chemistry","Endocrinology","Immunology","LPS","Apilarnil"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T10:45:13.061639Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}