{"doi":"10.1016/j.lfs.2020.117341","title":"The role of TFEB in tumor cell autophagy: Diagnostic and therapeutic opportunities","abstract":null,"journal":"Life Sciences","year":2020,"id":687777,"datarank":0.5101796072493234,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"self_citation_contribution":0.5101796072493234,"citation_network_contribution":0.0,"self_endowment_contribution":0.5101796072493234,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1214327,"name":"Vanessa Bianconi","orcid":"0000-0001-6987-9349","position":1,"is_corresponding":false},{"id":1568584,"name":"Matteo Pirro","orcid":null,"position":2,"is_corresponding":false},{"id":1796769,"name":"Hossein M. Orafai","orcid":null,"position":3,"is_corresponding":false},{"id":42413,"name":"Amirhossein Sahebkar","orcid":"0000-0002-8656-1444","position":4,"is_corresponding":false},{"id":1796768,"name":"Afsane Bahrami","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The role of TFEB in tumor cell autophagy: Diagnostic and therapeutic opportunities","abstract":"Autophagy is a conserved \"self-eating\" recycling process which removes aggregated or misfolded proteins, or defective organelles, to maintain cellular hemostasis. In the autophagy-lysosome pathway (ALP), clearance of unwanted debris and materials occurs through the generation of the autophagosome, a complex of double-membrane bounded vesicles that form around cytosolic cargos and catabolize their contents by fusion to lysosomes. In tumors, autophagy has dichotomous functions via preventing tumor initiation but promoting tumor progression. The basic helix-loop-helix leucine zipper transcription factor EB (TFEB) activates the promoters of genes encoding for proteins, which participate in this cellular degradative system by regulating lysosomal biogenesis, lysosomal acidification, lysosomal exocytosis and autophagy. In humans, disturbances of ALP are related to various pathological conditions. Recently, TFEB dysregulation was found to have a crucial pathogenic role in different tumors by modulating tumor cell autophagy. Notably, in renal cell carcinomas, different TFEB gene fusions were reported to promote oncogenic features. In this review, we discuss the role of TFEB in human cancers with a special focus on potential diagnostic and therapeutic implications.","is_dataset_classified":null,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31972208","pmcid":null,"openalex_id":"https://openalex.org/W3002308129","authors":[],"funders":[{"funder_name":"Cancer Research Center of Cancer Institute of Iran","grant_id":"37312-202-01-97","title":null},{"funder_name":"Biotechnology Development Council of the Islamic Republic of Iran","grant_id":"960206","title":null}],"total_grants":2,"fwci":2.8753,"citation_percentile":0.91876475,"influential_citations":0,"citation_trend":[{"year":2020,"count":4},{"year":2021,"count":5},{"year":2022,"count":7},{"year":2023,"count":5},{"year":2024,"count":6},{"year":2025,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0024320520300886?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0024320520300886?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.lfs.2020.117341","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31972208","host_type":"repository"}],"fields_of_study":["Autophagy in Disease and Therapy","Endoplasmic Reticulum Stress and Disease","Polyamine Metabolism and Applications"],"mesh_terms":["Humans","Neoplasms","Basic Helix-Loop-Helix Leucine Zipper Transcription Factors"],"keywords":["TFEB","Autophagy","Basic helix-loop-helix leucine zipper transcription factors","Cell biology","Lysosome","Autophagosome","Biology","Biogenesis","BAG3","Transcription factor","Gene","Biochemistry","DNA-binding protein","Enzyme","Malat1","Clear Network","Mit Family","Traslocation Renal Cell Carcinoma"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.26718660.v1","title":"Additional file 1 of A rare case of TFEB/6p21/VEGFA-amplified renal cell carcinoma diagnosed by whole-exome sequencing: clinicopathological and genetic feature report and literature review","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26718660","title":"Additional file 1 of A rare case of TFEB/6p21/VEGFA-amplified renal cell carcinoma diagnosed by whole-exome sequencing: clinicopathological and genetic feature report and literature review","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T22:43:08.214851Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}