{"doi":"10.1016/j.leukres.2007.11.006","title":"Therapy-related myelodysplastic syndrome and acute myeloid leukemia following treatment of acute myeloid leukemia: Possible role of cytarabine","abstract":null,"journal":"Leukemia Research","year":2008,"id":600868,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":857110,"name":"AnneMarie W. Block","orcid":null,"position":1,"is_corresponding":false},{"id":1540540,"name":"Sheila N. Sait","orcid":null,"position":2,"is_corresponding":false},{"id":1540541,"name":"Laurie A. Ford","orcid":null,"position":3,"is_corresponding":false},{"id":1540542,"name":"Maurice Barcos","orcid":null,"position":4,"is_corresponding":false},{"id":474925,"name":"Maria R. Baer","orcid":"0000-0002-9499-1348","position":5,"is_corresponding":false},{"id":1540539,"name":"Cecilia Arana-Yi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Therapy-related myelodysplastic syndrome and acute myeloid leukemia following treatment of acute myeloid leukemia: Possible role of cytarabine","abstract":"Therapy-related myelodysplastic syndrome and acute myeloid leukemia (t-MDS/t-AML) have been reported only rarely following treatment of AML. We report five patients treated for de novo AML who developed t-MDS/t-AML, all with chromosome 7 abnormalities, including -7, del(7)(q22q36) and del(7)(p11.22p22). All had been treated with cytarabine, topoisomerase 2 inhibitors and granulocyte or granulocyte-monocyte colony-stimulating factor and three with alkylating agents as part of autologous transplant regimens. These cases further document t-MDS/t-AML as a complication of therapy for AML. Presence of chromosome 7 abnormalities in patients with and without prior alkylating agent therapy suggests possible association with the antimetabolite cytarabine.","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18093651","pmcid":null,"openalex_id":"https://openalex.org/W2090384198","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"P30 CA16056","title":null}],"total_grants":1,"fwci":0.8235,"citation_percentile":0.73500239,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":3},{"year":2014,"count":3},{"year":2015,"count":1},{"year":2016,"count":4},{"year":2018,"count":2},{"year":2024,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0145212607004407?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0145212607004407?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.leukres.2007.11.006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18093651","host_type":"repository"}],"fields_of_study":["Acute Myeloid Leukemia Research","Retinoids in leukemia and cellular processes","Acute Lymphoblastic Leukemia research"],"mesh_terms":["Adult","Aged","Antineoplastic Agents","Chromosome Aberrations","Chromosomes, Human, Pair 7","Cytarabine","Female","Humans","Male","Middle Aged","Myelodysplastic Syndromes","Leukemia, Myeloid, Acute","Immunophenotyping"],"keywords":["Myeloid leukemia","Cytarabine","Medicine","Myelodysplastic syndromes","Myeloid","Leukemia","Oncology","Internal medicine","Cancer research","Immunology","Bone marrow"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T14:20:36.132182Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}