{"doi":"10.1016/j.lanhl.2024.100652","title":"Role of age and exposure duration in the association between metabolic syndrome and risk of incident dementia: a prospective cohort study","abstract":null,"journal":"The Lancet Healthy Longevity","year":2024,"id":630454,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":37291,"name":"Robert Luben","orcid":"0000-0002-5088-6343","position":1,"is_corresponding":false},{"id":635107,"name":"Shabina Hayat","orcid":"0000-0001-9068-8723","position":2,"is_corresponding":false},{"id":925488,"name":"Robert Talarico","orcid":null,"position":3,"is_corresponding":false},{"id":1633288,"name":"Naomi E Allen","orcid":null,"position":4,"is_corresponding":false},{"id":1364756,"name":"Elżbieta Kuźma","orcid":"0000-0001-7601-9961","position":5,"is_corresponding":false},{"id":29790,"name":"Thomas J. Littlejohns","orcid":"0000-0003-1177-6923","position":6,"is_corresponding":false},{"id":1633287,"name":"Danial Qureshi","orcid":"0000-0001-5703-2220","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Role of age and exposure duration in the association between metabolic syndrome and risk of incident dementia: a prospective cohort study","abstract":"BACKGROUND: Metabolic syndrome could be a modifiable risk factor for dementia. However, the effects of age and duration of exposure to metabolic syndrome on dementia risk remains underexplored. The aim of this study was to determine whether the association between metabolic syndrome and risk of dementia differs across mid-life versus late-life, and to explore how duration of metabolic syndrome affects this risk. METHODS: We conducted a population-based prospective study using data from the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) cohort. Metabolic syndrome was defined as having at least three of the following: elevated waist circumference, triglycerides, blood pressure, or glycated haemoglobin, or reduced HDL cholesterol. Incident all-cause dementia was ascertained through hospital inpatient, death, and mental health-care records. In full-cohort analyses, we studied 20 150 adults without dementia aged 50-79 years who attended baseline assessments. Cox proportional hazards models were used to estimate the association between metabolic syndrome and dementia in the full sample, and in mid-life (50-59 years and 60-69 years) and late-life (70-79 years). To assess duration of metabolic syndrome, group-based trajectory analysis was performed on 12 756 participants who attended at least two health assessments over 20 years. FINDINGS: =0·0040), but not in other age groups. In trajectory analysis, a prolonged duration of metabolic syndrome was associated with a significantly increased risk of developing dementia (1·26, 1·13-1·40) when compared to those with consistently low metabolic syndrome. No association was found for increasing metabolic syndrome (1·01, 0·88-1·17). INTERPRETATION: These findings provide insights into how certain age windows and time periods might differentially affect dementia risk in the context of metabolic syndrome, and highlight the importance of considering age and duration of exposure to metabolic syndrome when devising dementia prevention strategies. FUNDING: Canadian Institutes of Health Research-Institute of Aging, Oxford Population Health, and the Nicolaus and Margrit Langbehn Foundation.","is_dataset_classified":null,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39612929","pmcid":null,"openalex_id":"https://openalex.org/W4404736389","authors":[],"funders":[],"total_grants":0,"fwci":6.2318,"citation_percentile":0.97768648,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":13},{"year":2026,"count":8}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.lanhl.2024.100652","host_type":"journal"},{"url":"https://doi.org/10.1016/j.lanhl.2024.100652","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2666756824001788?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2666756824001788?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39612929","host_type":"repository"},{"url":"https://doaj.org/article/a47b2e1720ed45e196257dc8737fa5d1","host_type":"repository"}],"fields_of_study":["Dementia and Cognitive Impairment Research","Alzheimer's disease research and treatments","Diabetes, Cardiovascular Risks, and Lipoproteins","Humans","Metabolic Syndrome","Female","Dementia","Male","Aged","Middle Aged","Prospective Studies","Risk Factors","Incidence","Age Factors","Time Factors"],"mesh_terms":["Age Factors","Aged","Dementia","Female","Humans","Male","Middle Aged","Prospective Studies","Risk Factors","Time Factors","Incidence","Metabolic Syndrome"],"keywords":["Dementia","Prospective cohort study","Medicine","Cohort","Cohort study","Metabolic syndrome","Duration (music)","Association (psychology)","Internal medicine","Psychology","Disease","Obesity"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T21:20:26.005172Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}