{"doi":"10.1016/j.jvs.2021.08.104","title":"Opioid use in patients with peripheral arterial disease undergoing lower extremity bypass","abstract":null,"journal":"Journal of Vascular Surgery","year":2022,"id":633104,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":954379,"name":"Jeremy Albright","orcid":null,"position":1,"is_corresponding":false},{"id":1641277,"name":"Michael Englesbe","orcid":null,"position":2,"is_corresponding":false},{"id":580148,"name":"Nicholas Osborne","orcid":null,"position":3,"is_corresponding":false},{"id":1641278,"name":"Peter Henke","orcid":null,"position":4,"is_corresponding":false},{"id":449190,"name":"Ryan Howard","orcid":"0000-0001-9877-9603","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Opioid use in patients with peripheral arterial disease undergoing lower extremity bypass","abstract":"<h4>Objective</h4>Opioid use is common among patients with peripheral arterial disease (PAD), given that pain is a defining symptom. Unfortunately, long-term opioid use places patients at dramatically increased risk of overdose and death. Although surgical revascularization is extremely effective in alleviating ischemic pain related to PAD, it is unclear whether this practice results in the discontinuation of opioids after surgery. Therefore, we conducted the following study to investigate trends in opioid use before and after surgical bypass in patients with PAD, as well as the risk factors for continued opioid use after surgery.<h4>Methods</h4>We conducted a retrospective analysis of patients undergoing open lower extremity bypass for claudication or rest pain between June 1, 2017, and March 31, 2021. Patients were grouped according to whether they reported preoperative opioid use at the time of surgery. The primary outcome was continued opioid use at 30-day follow-up after discharge. A multivariable logistic regression was conducted to estimate the association of continued opioid use with patient characteristics, preoperative opioid use, and receiving a postoperative opioid prescription.<h4>Results</h4>Among 3873 patients undergoing surgery, the mean age was 65.7 (10.2) years and 2650 (68.4%) patients were male. There were 913 patients (23.6%) who used opioids preoperatively and hydrocodone was the most common preoperative opioid (583 [63.9%]). At discharge, 2506 patients (64.7%) received a postoperative opioid prescription. Postoperative opioid prescriptions were significantly more common for preoperative opioid users than opioid-naïve patients (813 [89.0%] vs 1693 [57.2%]; P < .001) and were significantly larger in size (24.3 [21.1] pills vs 19.9 [10.5] pills; P < .001). On 30-day follow-up, 522 preoperative opioid users (61.3%) and 616 opioid-naïve patients (28.4%) reported that they were still using opioids (P < .001). Continued opioid use at follow-up was associated with preoperative opioid use (adjusted odds ratio, 3.23; 95% confidence interval, 2.70-3.89) and receiving a postoperative opioid prescription (adjusted odds ratio, 10.83; 95% confidence interval, 7.96-15.06).<h4>Conclusions</h4>Most patients with PAD who use opioids preoperatively do not discontinue opioids after lower extremity bypass. Moreover, a significant proportion of previously opioid-naïve patients are still using opioids 1 month after surgery. In both cases, postoperative opioid prescriptions had the strongest association with continued opioid use. These findings underscore the need for improved prescribing practice and increased attentiveness to discontinuation of unnecessary medications after surgery.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34606956","pmcid":"PMC9153650","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Institute of Diabetes and Digestive and Kidney Diseases","grant_id":"5T32DK108740-05","title":"Obesity Surgery Scientist Training Program"},{"funder_name":"NIDDK NIH HHS","grant_id":"T32 DK108740","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"K08 HL144924","title":null},{"funder_name":"Blue Cross Blue Shield of Michigan Foundation","grant_id":"","title":null},{"funder_name":"National Institute on Drug Abuse","grant_id":"","title":null},{"funder_name":"Michigan Department of Health and Human Services","grant_id":"","title":null}],"total_grants":6,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"Elsevier Non-Commercial","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9153650","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0741521421021741?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0741521421021741?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jvs.2021.08.104","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/34606956","host_type":""},{"url":"https://dx.doi.org/10.1016/j.jvs.2021.08.104","host_type":""}],"fields_of_study":["03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Lower Extremity","Humans","Intermittent Claudication","Analgesics, Opioid","Pain Measurement","Treatment Outcome","Drug Administration Schedule","Risk Assessment","Risk Factors","Retrospective Studies","Time Factors","Adult","Aged","Middle Aged","Drug Utilization","Female","Male","Drug Prescriptions","Vascular Grafting","Peripheral Arterial Disease","Practice Patterns, Physicians'","Postoperative Pain"],"keywords":["Pain","Surgery","Opioids","Peripheral Arterial Disease","Bypass","Adult","Male","Postoperative Pain","Time Factors","Intermittent Claudication","Middle Aged","Drug Prescriptions","Risk Assessment","Drug Administration Schedule","Drug Utilization","Analgesics, Opioid","Lower Extremity","Risk Factors","Humans","Female","Practice Patterns, Physicians'","Aged","Pain Measurement","Retrospective Studies"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T11:00:29.175743Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}