{"doi":"10.1016/j.jvir.2025.01.044","title":"Assessment of Catheter-Directed Thrombolysis and Histotripsy Treatment for Deep Vein Thrombosis","abstract":"PURPOSE: The hypothesis of this study was that histotripsy, an ultrasound therapy that disrupts tissue mechanically through the action of bubble clouds, increases the short-term rate of acute thrombus clearance for catheter-directed thrombolysis (CDT) in an animal model. MATERIALS AND METHODS: Thrombi formed in the femoral vein of pigs were treated with CDT, histotripsy, or CDT and histotripsy (histotripsy+). Ultrasound (B-mode and color Doppler) and contrast fluoroscopy imaging data were scored by 4 observers for semiquantitative evaluation of each arm with ordinal regression models. Further, B-mode images were manually annotated by 3 observers to quantify the thrombus clearance rate. RESULTS: A total of 27 thrombi (2.0 cm [SD ± 0.4] in length) in 27 animals were considered in this study (N = 8 for CDT, N = 9 for histotripsy, and N = 10 for histotripsy+). The mean treatment duration was 20.2 minutes (SD ± 1.3). The ordinal regression models indicated that the thrombus clearance rate increased for histotripsy+ relative to CDT based on B-mode and color Doppler but not fluoroscopy (P = .015, P = .001, and P = .900, respectively). Manual annotation of B-mode images denoted that histotripsy+ had an increased thrombus clearance rate relative to CDT and histotripsy (P = .001 and P = .022, respectively). Petechial hemorrhage was present in the perivascular soft tissue for 2 cases with histotripsy and 1 case with histotripsy+. CONCLUSIONS: The clearance of acute thrombus was similar for treatment with CDT or histotripsy. Combining these individual approaches further increased the rate of thrombus clearance based on multiple imaging metrics.","journal":"Journal of Vascular and Interventional Radiology","year":2025,"id":542922,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9563,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1432701,"name":"Erik Saucedo","orcid":null,"position":1,"is_corresponding":false},{"id":1145443,"name":"Katia Flores Basterrechea","orcid":"0009-0006-6076-3116","position":2,"is_corresponding":false},{"id":509537,"name":"Shumeng Yang","orcid":"0000-0001-5692-864X","position":3,"is_corresponding":false},{"id":704990,"name":"Kevin J. Haworth","orcid":"0000-0002-6578-2440","position":4,"is_corresponding":false},{"id":232454,"name":"Christy K. Holland","orcid":"0000-0003-3382-7170","position":5,"is_corresponding":false},{"id":957932,"name":"John M. Racadio","orcid":"0000-0002-3697-2472","position":6,"is_corresponding":false},{"id":571424,"name":"Adam D. Maxwell","orcid":"0000-0001-5876-0545","position":7,"is_corresponding":false},{"id":570230,"name":"John Cursio","orcid":"0000-0003-2131-1767","position":8,"is_corresponding":false},{"id":712728,"name":"Geoffrey D. Wool","orcid":"0000-0002-3335-2905","position":9,"is_corresponding":false},{"id":1432702,"name":"Allison M. Ostdiek","orcid":null,"position":10,"is_corresponding":false},{"id":712731,"name":"Osman Ahmed","orcid":"0000-0003-2440-2437","position":11,"is_corresponding":false},{"id":1432365,"name":"Jonathan D. Paul","orcid":"0000-0002-2174-4530","position":12,"is_corresponding":false},{"id":1346199,"name":"Mikin Patel","orcid":"0000-0001-8715-2063","position":13,"is_corresponding":false},{"id":500848,"name":"Kenneth B. Bader","orcid":"0000-0003-2384-3150","position":14,"is_corresponding":false},{"id":1218169,"name":"Kevin Zhao","orcid":"0009-0004-4573-9412","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T02:53:00.171379Z","pmid":"39890017","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}