{"doi":"10.1016/j.juro.2011.05.054","title":"Increased Risk of Overall and Cardiovascular Mortality After Radical Nephrectomy for Renal Cell Carcinoma 2 cm or Less","abstract":null,"journal":"Journal of Urology","year":2011,"id":599282,"datarank":0.6628260911694899,"base_score":4.418840607796598,"endowment":4.418840607796598,"self_citation_contribution":0.6628260911694899,"citation_network_contribution":0.0,"self_endowment_contribution":0.6628260911694899,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":82,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1535875,"name":"Gina M. Badalato","orcid":null,"position":1,"is_corresponding":false},{"id":1535876,"name":"Max Pitman","orcid":null,"position":2,"is_corresponding":false},{"id":1034286,"name":"James M. McKiernan","orcid":"0000-0001-5866-6348","position":3,"is_corresponding":false},{"id":418315,"name":"Max Kates","orcid":"0000-0003-1166-7225","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Increased Risk of Overall and Cardiovascular Mortality After Radical Nephrectomy for Renal Cell Carcinoma 2 cm or Less","abstract":"PURPOSE: We used a large, population based registry to assess whether a difference in overall and cardiovascular survival may exist between radical nephrectomy and partial nephrectomy for renal cell carcinoma 2 cm or less. MATERIALS AND METHODS: From the SEER (Surveillance, Epidemiology and End Results) registry we identified 4,216 patients with histologically confirmed renal cell carcinoma 2 cm or less who were treated with partial or radical nephrectomy. Patient and tumor characteristics were compared between the 2 patient groups. Multivariate logistic regression was done to predict the odds of undergoing radical nephrectomy. Cardiovascular survival and overall survival were compared between the 2 cohorts, adjusting for patient and tumor characteristics. RESULTS: Overall 2,301 patients (55%) underwent partial nephrectomy. Partial nephrectomy use steadily increased during the study period from 27% of all cases in 1998 to 66% in 2007. Patients who underwent partial nephrectomy were an average of 2.5 years younger than those treated with radical nephrectomy (56.4 vs 58.9 years, p <0.001). They were more likely to be white and from the western or northeastern United States. Older age was the only independent predictor of radical nephrectomy (OR 1.02, 95% CI 1.01-1.03). When controlling for patient characteristics and surgery year, radical nephrectomy was associated with worse overall mortality (HR 2.24, 95% CI 1.75-2.84) and cardiovascular mortality (HR 2.53, 95% CI 1.51-4.23). CONCLUSIONS: Radical nephrectomy is associated with worse overall and cardiovascular survival compared to partial nephrectomy in patients with localized renal cell carcinoma 2 cm or less. These findings justify the widespread application of nephron sparing techniques to treat localized kidney cancer.","is_dataset_classified":null,"base_score":4.418840607796598,"endowment":4.418840607796598,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21849201","pmcid":null,"openalex_id":"https://openalex.org/W2006150388","authors":[],"funders":[],"total_grants":0,"fwci":5.1974,"citation_percentile":0.95678986,"influential_citations":0,"citation_trend":[{"year":2012,"count":10},{"year":2013,"count":3},{"year":2014,"count":8},{"year":2015,"count":4},{"year":2016,"count":5},{"year":2017,"count":2},{"year":2018,"count":5},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":11},{"year":2022,"count":6},{"year":2023,"count":8},{"year":2024,"count":4},{"year":2025,"count":6},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0022534711040468?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022534711040468?httpAccept=text/plain","host_type":"publisher"},{"url":"http://www.jurology.com/doi/pdf/10.1016/j.juro.2011.05.054","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.juro.2011.05.054","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21849201","host_type":"repository"}],"fields_of_study":["Renal cell carcinoma treatment","Multiple and Secondary Primary Cancers","Bladder and Urothelial Cancer Treatments"],"mesh_terms":["Carcinoma, Renal Cell","Cardiovascular Diseases","Female","Humans","Kidney Neoplasms","Male","Middle Aged","Nephrectomy","Risk Factors","Survival Rate","Proportional Hazards Models","Disease-Free Survival"],"keywords":["Medicine","Renal cell carcinoma","Nephrectomy","Urology","Carcinoma","Internal medicine","Oncology","Kidney"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T21:50:16.060976Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}