{"doi":"10.1016/j.jtocrr.2023.100489","title":"ALK Deletion Exons 2 to 19: Case Report of a Rare ALK Inhibitor–Responsive Lung Cancer Driver Oncogene","abstract":"ALK internal deletions of nonkinase domain exons occur in 0.01% of lung cancers with ALK genomic aberrations. We report a lung adenocarcinoma with a previously undescribed somatic ALK deletion of exons 2 to 19 with dramatic and sustained (>23 mo) response to alectinib. Our and other reported cases with ALK nonkinase domain deletions (between introns and exons 1–19) can display positive results in nonsequencing-based lung cancer diagnostic tests (such as immunohistochemistry) used to screen for more common ALK rearrangements. This case report emphasizes that “ALK-driven” lung cancers should be expanded to encompass those harboring not only ALK rearrangements with other genes but also ALK nonkinase domain deletions.","journal":"JTO Clinical and Research Reports","year":2023,"id":403300,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":610920,"name":"Emmeline C. Academia","orcid":"0000-0001-7514-1754","position":1,"is_corresponding":false},{"id":1181106,"name":"Soravis A. Osataphan","orcid":null,"position":2,"is_corresponding":false},{"id":297160,"name":"Deepa Rangachari","orcid":"0000-0001-9710-6757","position":3,"is_corresponding":false},{"id":1181107,"name":"Sheida Sharifi","orcid":null,"position":4,"is_corresponding":false},{"id":297161,"name":"Paul A. VanderLaan","orcid":"0000-0002-7234-5652","position":5,"is_corresponding":false},{"id":297163,"name":"Daniel B. Costa","orcid":"0000-0002-0689-395X","position":6,"is_corresponding":false},{"id":1181105,"name":"Zachary R. Schoepflin","orcid":null,"position":0,"is_corresponding":true}],"reference_count":7,"raw_metadata":null,"created_at":"2026-07-19T01:20:36.280647Z","pmid":"36994308","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}