{"doi":"10.1016/j.jtha.2023.11.014","title":"Genetic and nongenetic drivers of platelet reactivity in healthy Tanzanian individuals","abstract":"BACKGROUND: Platelets play a key role in hemostasis, inflammation, and cardiovascular diseases. Platelet reactivity is highly variable between individuals. The drivers of this variability in populations from Sub-Saharan Africa remain largely unknown. OBJECTIVES: We aimed to investigate the nongenetic and genetic determinants of platelet reactivity in healthy adults living in a rapidly urbanizing area in Northern Tanzania. METHODS: Platelet activation and reactivity were measured by platelet P-selectin expression and the binding of fibrinogen in unstimulated blood and after ex vivo stimulation with adenosine diphosphate and PAR-1 and PAR-4 ligands. We then analyzed the associations of platelet parameters with host genetic and nongenetic factors, environmental factors, plasma inflammatory markers, and plasma metabolites. RESULTS: ) as well as a number of variants in the PAR4 gene (F2RL3) that were associated with PAR4-induced reactivity. CONCLUSION: Our study uncovered factors that determine variation in platelet reactivity in a population in East Africa that is rapidly transitioning to an urban lifestyle, including the importance of genetic ancestry and the gradual abandoning of the traditional East African diet.","journal":"Journal of Thrombosis and Haemostasis","year":2023,"id":368393,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":640037,"name":"Godfrey S. Temba","orcid":"0000-0002-1093-3037","position":1,"is_corresponding":false},{"id":1126347,"name":"Nadira Vadaq","orcid":"0000-0002-1746-8844","position":2,"is_corresponding":false},{"id":1126774,"name":"Judith Njau","orcid":null,"position":3,"is_corresponding":false},{"id":1126348,"name":"Collins K. Boahen","orcid":"0000-0002-9640-8857","position":4,"is_corresponding":false},{"id":318000,"name":"Bongani B. Nkambule","orcid":"0000-0001-8846-1992","position":5,"is_corresponding":false},{"id":356089,"name":"Florian Thibord","orcid":"0000-0003-2229-8322","position":6,"is_corresponding":false},{"id":108706,"name":"Ming‐Huei Chen","orcid":"0000-0003-3551-8726","position":7,"is_corresponding":false},{"id":65412,"name":"Tal Pecht","orcid":"0000-0002-6442-0560","position":8,"is_corresponding":false},{"id":640039,"name":"Furaha S. Lyamuya","orcid":"0000-0002-2319-8246","position":9,"is_corresponding":false},{"id":299822,"name":"Vinod Kumar","orcid":"0000-0002-2775-6049","position":10,"is_corresponding":false},{"id":104377,"name":"Mihai G. Netea","orcid":"0000-0003-2421-6052","position":11,"is_corresponding":false},{"id":341832,"name":"Blandina T. Mmbaga","orcid":"0000-0002-5550-1916","position":12,"is_corresponding":false},{"id":65665,"name":"André van der Ven","orcid":"0000-0003-1833-3391","position":13,"is_corresponding":false},{"id":24979,"name":"Andrew D. Johnson","orcid":"0000-0001-6369-5178","position":14,"is_corresponding":false},{"id":640040,"name":"Quirijn de Mast","orcid":"0000-0001-6056-157X","position":15,"is_corresponding":false},{"id":640038,"name":"Vesla Kullaya","orcid":"0000-0001-6120-3985","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T01:15:20.453499Z","pmid":"38029856","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}