{"doi":"10.1016/j.jtct.2022.02.004","title":"Post-Transplantation Cyclophosphamide-Based Graft- versus-Host Disease Prophylaxis with Nonmyeloablative Conditioning for Blood or Marrow Transplantation for Myelofibrosis","abstract":"We describe outcomes after post-transplantation cyclophosphamide and nonmyeloablative conditioning-based allogeneic blood or marrow transplantation for myelofibrosis using matched or mismatched related or unrelated donors. The conditioning regimen consisted of fludarabine, cyclophosphamide, and total body irradiation. Forty-two patients were included, with a median age of 63 years, of whom 19% had Dynamic International Prognostic Scoring System (DIPSS)-plus intermediate-1 risk, 60% had intermediate-2 risk, and 21% had high-risk disease, and 60% had at least 1 high-risk somatic mutation. More than 90% of patients engrafted neutrophils, at a median of 19.5 days, and 7% experienced graft failure. At 1 year and 3 years, respectively, overall survival was 65% and 60%, relapse-free survival was 65% and 31%, relapse was 5% and 40%, and nonrelapse mortality was 30% and 30%. Acute graft-versus-host disease grade 3-4 was seen in 17% of patients at 1 year, and chronic graft-versus-host disease requiring systemic therapy in occurred in 12% patients. Spleen size ≥17 cm or prior splenectomy was associated with inferior relapse-free survival (hazard ratio [HR], 3.50; 95% confidence interval [CI], 1.18 to 10.37; P = .02) and higher relapse rate (subdistribution HR [SDHR] not calculable; P = .01). Age >60 years (SDHR, 0.26; 95% CI, 0.08 to 0.80, P = .02) and receipt of peripheral blood grafts (SDHR, 0.34; 95% CI, 0.11 to 0.99; P = .05) were associated with a lower risk of relapse. In our limited sample, the presence of a high-risk mutation was not statistically significantly associated with an inferior outcome, although ASXL1 was suggestive of inferior survival (SDHR, 2.36; 95% CI, 0.85 to 6.6; P = .09). Overall, this approach shows outcomes comparable those of to previously reported approaches and underscores the importance of spleen size in the evaluation of transplantation candidates.","journal":"Transplantation and Cellular Therapy","year":2022,"id":249726,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":581464,"name":"Hua‐Ling Tsai","orcid":"0000-0001-8388-6297","position":1,"is_corresponding":false},{"id":259085,"name":"Amy E. 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Gladstone","orcid":"0000-0001-8484-2990","position":9,"is_corresponding":false},{"id":259089,"name":"Philip Imus","orcid":"0000-0001-8563-195X","position":10,"is_corresponding":false},{"id":486780,"name":"Jonathan Webster","orcid":"0000-0003-3647-6345","position":11,"is_corresponding":false},{"id":487656,"name":"Gabrielle T. Prince","orcid":null,"position":12,"is_corresponding":false},{"id":267503,"name":"Gabriel Ghiaur","orcid":"0000-0002-3955-7944","position":13,"is_corresponding":false},{"id":304666,"name":"B. Douglas Smith","orcid":"0000-0002-0903-7390","position":14,"is_corresponding":false},{"id":267500,"name":"Syed Abbas Ali","orcid":"0000-0001-6014-1559","position":15,"is_corresponding":false},{"id":783565,"name":"Alexander J. Ambinder","orcid":"0000-0003-0855-9653","position":16,"is_corresponding":false},{"id":320772,"name":"W. Brian Dalton","orcid":"0000-0002-1314-0534","position":17,"is_corresponding":false},{"id":430280,"name":"Christian B. 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