{"doi":"10.1016/j.jtbi.2020.110246","title":"A mathematical model of adiponectin resistance","abstract":null,"journal":"Journal of Theoretical Biology","year":2020,"id":606893,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1558186,"name":"Nishant Namdev","orcid":null,"position":1,"is_corresponding":false},{"id":1267619,"name":"Awanish Kumar","orcid":"0000-0001-8735-479X","position":2,"is_corresponding":false},{"id":1558184,"name":"Arvind Kumar Sinha","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A mathematical model of adiponectin resistance","abstract":"Adiponectin is often associated with obesity. The obese body displays a significant decrease in adiponectin expression and plasma levels. Higher adiponectin also results in lower expression of pro-inflammatory cytokine TNF-α from adipose tissue. Low adiponectin levels show to exist significantly in the case of insulin resistance. Adiponectin levels are found to be significantly lower in people with type 2 diabetes. In this paper, we proposed a mathematical model of the adiponectin - adiponectin receptors framework, based on the assumption that the secretion of adiponectin is inversely proportional to fat mass. Here, we show that an increase in obesity or adiposity results in a decrease in the adiponectin plasma level, which contributes to the development of adiponectin resistance. In this model, we have used different parameters and their default values, to perform a simulation based on the model. Further, experimentally, the plasma adiponectin concentration is ( ≈  0.015) significantly lowered in the diabetic group compared to the non-diabetic group. In this model, we have obtained the plasma adiponectin concentration level ( ≈  0.014) in the simulation process. So this model is only differing from 1 × 10<sup>-3</sup> significant digits. We have achieved the degree of accuracy of adiponectin resistance is 93.33%. Therefore, these advances offer novel insights into the mathematical approach.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32179108","pmcid":null,"openalex_id":"https://openalex.org/W3011060600","authors":[],"funders":[],"total_grants":0,"fwci":0.8214,"citation_percentile":0.72025753,"influential_citations":0,"citation_trend":[{"year":2021,"count":3},{"year":2022,"count":3},{"year":2024,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0022519320301016?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022519320301016?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jtbi.2020.110246","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32179108","host_type":"repository"}],"fields_of_study":["Adipokines, Inflammation, and Metabolic Diseases","Adipose Tissue and Metabolism","Blood properties and coagulation"],"mesh_terms":["Diabetes Mellitus, Type 2","Humans","Insulin Resistance","Models, Biological","Obesity","Adiponectin"],"keywords":["Adiponectin","Insulin resistance","Internal medicine","Adipose tissue","Endocrinology","Obesity","Type 2 diabetes","Adiponectin receptor 1","Diabetes mellitus","Medicine","Chemistry","Modeling","Fat Mass","Rough Set"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T05:23:12.157007Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}