{"doi":"10.1016/j.jss.2023.07.022","title":"Predictors of Mortality in Extracorporeal Membrane Oxygenation Support Patients Following Major Trauma","abstract":null,"journal":"Journal of Surgical Research","year":2023,"id":671702,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1754868,"name":"Ander Dorken-Gallastegi","orcid":null,"position":1,"is_corresponding":false},{"id":1754869,"name":"Benjamin C. Renne","orcid":null,"position":2,"is_corresponding":false},{"id":1754870,"name":"Spencer Lord","orcid":null,"position":3,"is_corresponding":false},{"id":187160,"name":"Shuhan He","orcid":"0000-0002-9902-5077","position":4,"is_corresponding":false},{"id":1754871,"name":"Elaine P.X. van Ee","orcid":null,"position":5,"is_corresponding":false},{"id":1754872,"name":"Dias Argandykov","orcid":null,"position":6,"is_corresponding":false},{"id":1754873,"name":"Jefferson A. Proaño-Zamudio","orcid":null,"position":7,"is_corresponding":false},{"id":1090666,"name":"John O. Hwabejire","orcid":"0000-0003-0759-2638","position":8,"is_corresponding":false},{"id":301517,"name":"Haytham M.A. Kaafarani","orcid":"0000-0002-4682-9135","position":9,"is_corresponding":false},{"id":313113,"name":"George C. Velmahos","orcid":null,"position":10,"is_corresponding":false},{"id":673971,"name":"Jarone Lee","orcid":"0000-0002-4532-8523","position":11,"is_corresponding":false},{"id":1754867,"name":"Joep J.J. Ouwerkerk","orcid":"0000-0001-9436-3002","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Predictors of Mortality in Extracorporeal Membrane Oxygenation Support Patients Following Major Trauma","abstract":"<h4>Introduction</h4>The usage of extracorporeal membrane oxygenation (ECMO) in trauma patients has increased significantly within the past decade. Despite increased research on ECMO application in trauma patients, there remains limited data on factors predicting morbidity and mortality outcome. Therefore, the primary objective of this study is to describe patient characteristics that are independently associated with mortality in ECMO therapy in trauma patients, to further guide future research.<h4>Methods</h4>This retrospective study was conducted using the Trauma Quality Improvement Program database from 2010 to 2019. All adult (age ≥ 16 y) trauma patients that utilized ECMO were included. A Significant differences (P < 0.05) in demographic and clinical characteristics between groups were calculated using an independent t-test for normal distributed continuous values, a Mann-Whitney U test for non-normal distributed values, and a Pearson chi-square test for categorical values. A multivariable regression model was used to identify independent predictors for mortality. A survival flow chart was constructed by using the strongest predictive value for mortality and using the optimal cut-off point calculated by the Youden index.<h4>Results</h4>Five hundred forty-two patients were included of whom 205 died. Multivariable analysis demonstrated that the female gender, ECMO within 4 h after presentation, a decreased Glasgow Coma Scale, increased age, units of blood in the first 4 h, and abbreviated injury score for external injuries were independently associated with mortality in ECMO trauma patients. It was found that an external abbreviated injury score of ≥3 had the strongest predictive value for mortality, as patients with this criterion had an overall 29.5% increased risk of death.<h4>Conclusions</h4>There is an ongoing increasing trend in the usage of ECMO in trauma patients. This study has identified multiple factors that are individually associated with mortality. However, more research must be done on the association between mortality and noninjury characteristics like Pao2/Fio2 ratio, acute respiratory distress syndrome classification, etc. that reflect the internal state of the patient.","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37567030","pmcid":null,"openalex_id":"https://openalex.org/W4385688290","authors":[],"funders":[],"total_grants":0,"fwci":0.5627,"citation_percentile":0.57565789,"influential_citations":0,"citation_trend":[{"year":2024,"count":2},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0022480423003256?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022480423003256?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jss.2023.07.022","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37567030","host_type":"repository"}],"fields_of_study":["Mechanical Circulatory Support Devices","Medical and Biological Ozone Research","Trauma and Emergency Care Studies","Humans","Extracorporeal Membrane Oxygenation","Female","Male","Retrospective Studies","Adult","Middle Aged","Wounds and Injuries","Risk Factors","Aged","Young Adult","Glasgow Coma Scale","Injury Severity Score","Age Factors"],"mesh_terms":["Adult","Age Factors","Aged","Female","Humans","Male","Middle Aged","Retrospective Studies","Risk Factors","Wounds and Injuries","Extracorporeal Membrane Oxygenation","Glasgow Coma Scale","Injury Severity Score","Young Adult"],"keywords":["Medicine","Glasgow Coma Scale","Extracorporeal membrane oxygenation","Injury Severity Score","Revised Trauma Score","Youden's J statistic","Mann–Whitney U test","Retrospective cohort study","Mortality rate","Emergency medicine","Poison control","Injury prevention","Surgery","Internal medicine","Predictive value","Mortality","Trauma"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T04:05:27.141852Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}