{"doi":"10.1016/j.jss.2019.07.009","title":"Herpes Virus Entry Mediator (HVEM): A Novel Potential Mediator of Trauma-Induced Immunosuppression","abstract":null,"journal":"Journal of Surgical Research","year":2020,"id":632200,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":765521,"name":"Nicholas J. Shubin","orcid":"0000-0001-7709-4496","position":1,"is_corresponding":false},{"id":574488,"name":"Sean F. Monaghan","orcid":"0000-0003-1490-3043","position":2,"is_corresponding":false},{"id":878012,"name":"Chyna C. Gray","orcid":null,"position":3,"is_corresponding":false},{"id":506696,"name":"Alfred Ayala","orcid":"0000-0002-5034-2995","position":4,"is_corresponding":false},{"id":736441,"name":"Daithi S. Heffernan","orcid":"0000-0002-3417-2893","position":5,"is_corresponding":false},{"id":892054,"name":"Michelle E. Wakeley","orcid":"0000-0001-7850-5744","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Herpes Virus Entry Mediator (HVEM): A Novel Potential Mediator of Trauma-Induced Immunosuppression","abstract":"<h4>Background</h4>Herpes virus entry mediator (HVEM) is a coinhibitory molecule which can both stimulate and inhibit host immune responses. Altered expression of HVEM and its ligands is associated with increased nosocomial infections in septic patients. We hypothesize critically ill trauma patients will display increased lymphocyte HVEM expression and that such alteration is predictive of infectious events.<h4>Materials and methods</h4>Trauma patients prospectively enrolled from the ICU were compared with healthy controls. Leukocytes were isolated from whole blood, stained for CD3 (lymphocytes) and HVEM, and evaluated by flow cytometry. Charts were reviewed for injuries sustained, APACHE II score, hospital course, and secondary infections.<h4>Results</h4>Trauma patients (n = 31) were older (46.7 ± 2.4 versus 36.8 ± 2.1 y; P = 0.03) than healthy controls (n = 10), but matched for male sex (74% versus 60%; P = 0.4). Trauma patients had higher presenting WBC (13.9 ± 1.3 versus 5.6 ± 0.5 × 10<sup>6</sup>/mL; P = 0.002), lower percentage of CD3<sup>+</sup> lymphocytes (7.5% ± 0.8 versus 22.5% ± 0.9; P < 0.001), but significantly greater expression of HVEM<sup>+</sup>/CD3<sup>+</sup> lymphocytes (89.6% ± 1.46 versus 67.3% ± 1.7; P < 0.001). Among trauma patients, secondary infection during the hospitalization was associated with higher APACHE II scores (20.6 ± 1.6 versus 13.6 ± 1.4; P = 0.03) and markedly lower CD3<sup>+</sup> lymphocyte HVEM expression (75% ± 2.6 versus 93% ± 0.7; P < 0.01).<h4>Conclusions</h4>HVEM expression on CD3<sup>+</sup> cells increases after trauma. Patients developing secondary infections have less circulating HVEM<sup>+</sup>CD3<sup>+</sup>. This implies HVEM signaling in lymphocytes plays a role in maintaining host defense to infection in after trauma. HVEM expression may represent a marker of infectious risk as well as a potential therapeutic target, modulating immune responses to trauma.","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31522034","pmcid":"PMC6900447","openalex_id":"https://openalex.org/W2973207385","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM065085","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"K08 GM110495","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R25 GM083270","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"P20 GM103652","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R35 GM118097","title":null},{"funder_name":"National Institutes of Health","grant_id":"","title":null}],"total_grants":6,"fwci":0.8803,"citation_percentile":0.74242981,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":2},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":1},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"green","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6900447","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6900447","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0022480419305049?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022480419305049?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jss.2019.07.009","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31522034","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC6900447","host_type":"repository"}],"fields_of_study":["Herpesvirus Infections and Treatments","Immune Response and Inflammation","interferon and immune responses","APACHE","Adult","Biomarkers","CD3 Complex","Case-Control Studies","Female","Healthy Volunteers","Humans","Immune Tolerance","Infections","Lymphocytes","Male","Middle Aged","Prospective Studies","Receptors, Tumor Necrosis Factor, Member 14","Wounds and Injuries"],"mesh_terms":["Adult","Female","Humans","Immune Tolerance","Infections","Lymphocytes","Male","Middle Aged","Prospective Studies","Wounds and Injuries","Biomarkers","Case-Control Studies","CD3 Complex","APACHE","Receptors, Tumor Necrosis Factor, Member 14","Healthy Volunteers"],"keywords":["CD3","Immunosuppression","Medicine","Flow cytometry","Mediator","Immunology","Virus","Immune system","Lymphocyte","Internal medicine","Gastroenterology","CD8","Lymphocytes","Trauma","HVEM"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T09:08:22.782599Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}