{"doi":"10.1016/j.jshs.2022.06.002","title":"Exercise regulates cardiac metabolism: Sex does matter","abstract":null,"journal":"Journal of Sport and Health Science","year":2022,"id":617106,"datarank":0.2612842069793256,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.019868520114210492,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.019868520114210492,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1474491,"name":"Meiyu Hu","orcid":null,"position":1,"is_corresponding":false},{"id":861960,"name":"Michail Spanos","orcid":"0000-0003-1205-4201","position":2,"is_corresponding":false},{"id":1411448,"name":"Guoping Li","orcid":"0000-0002-0134-2593","position":3,"is_corresponding":false},{"id":1591259,"name":"Stephen C Kolwicz","orcid":null,"position":4,"is_corresponding":false},{"id":251877,"name":"Junjie Xiao","orcid":"0000-0002-9202-0003","position":5,"is_corresponding":false},{"id":29977,"name":"Tingting Yang","orcid":"0000-0002-7406-2170","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Exercise regulates cardiac metabolism: Sex does matter","abstract":"Cardiac substrate utilization remains a critical focus for the research community. 1Research has acknowledged the role of metabolic flexibility in the development and progression of cardiac dysfunction during a variety of diseases and conditions. 2,3Under resting basal conditions, the heart relies on fatty acid metabolism as the primary energy source with glucose, lactate, ketone bodies, pyruvate, acetate, and branched-chain amino acids contributing as substrates depending on substrate availability, hormonal status, and myocardial conditioning. 4In addition to pathological states, physiological states, such as acute exercise, induce dynamic changes in substrate metabolism, including nearly a 10-fold increase in myocardial oxygen consumption. 3,5To meet the increased demand for energy during and after a bout of exercise, the heart muscle must exhibit metabolic flexibility and selectively utilize different substrates for adenosine triphosphate production.Moreover, metabolic substrate adaptations depend on the frequency, intensity, duration, and mode of exercise while multiple metabolic fluxes, such as the use, storage and mobilization of substrates must be coordinated to maintain energy homeostasis. 1,2Although many different processes of exercise-induced regulation and metabolic remodeling have been identified, 3À5 the effect of exercise on cellular metabolism and the landscape of metabolic pathway regulation in response to both acute exercise and chronic exercise training remain unclear.Research evaluating changes in cardiac metabolism in response to chronic exercise training have produced inconsistent findings related to the contribution of glycolysis, glucose oxidation, and lipid oxidation in the hearts of exercise-adapted","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35688381","pmcid":"PMC9338330","openalex_id":"https://openalex.org/W4282014710","authors":[],"funders":[{"funder_name":"National Key Research and Development Program of China","grant_id":"2018YFE0113500","title":null},{"funder_name":"American Heart Association","grant_id":"20AIREA35080151","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81911540486","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82020108002","title":null},{"funder_name":"Shanghai Municipal Education Commission","grant_id":"19SG34","title":null},{"funder_name":"Science and Technology Commission of Shanghai Municipality","grant_id":"20DZ2255400","title":null},{"funder_name":"Science and Technology Commission of Shanghai Municipality","grant_id":"21XD1421300","title":null},{"funder_name":"American Heart Association-American Stroke Association","grant_id":"20AIREA35080151 - STEPHEN KOLWICZ","title":null}],"total_grants":8,"fwci":1.2033,"citation_percentile":0.80825334,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":2},{"year":2024,"count":1}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S2095254622000606/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S2095254622000606/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2095254622000606?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2095254622000606?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jshs.2022.06.002","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35688381","host_type":"repository"},{"url":"https://doaj.org/article/e3a2e809e00147eeb20a90cf3d54d127","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9338330","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9338330","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9338330?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Cardiovascular and exercise physiology","Cardiovascular Effects of Exercise","Adipose Tissue and Metabolism","Exercise","Physical Exertion"],"mesh_terms":["Physical Exertion","Exercise"],"keywords":["Metabolism","Internal medicine","Medicine","Endocrinology","Physiology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Gender equality"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T00:51:36.189427Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}