{"doi":"10.1016/j.jsbmb.2025.106898","title":"Vitamin D is glucoprotective in aging males but not females","abstract":"Vitamin D supplementation is linked to many beneficial health outcomes in the geriatric population, such as decreased mortality, epigenetic aging, and fracture risk. Conversely, type 2 diabetes is strongly linked to vitamin D deficiency in older adults. However, there is a discrepancy between clinical trials in adults on the efficacy of vitamin D treatment in prediabetes and diabetes. In addition, human data indicates there may be sexual dimorphism in the effect of vitamin D deficiency on dysglycemia that is more pronounced in men. These incongruities may be due to our limited understanding of the underlying mechanisms of vitamin D in glucose homeostasis among its vast target tissues across the body. Here we describe the physiological effects of vitamin D supplementation in an aged, non-obese mouse model on glucose homeostasis and associated tissue-specific gene regulation. Specifically, we found that 1) increased dietary vitamin D intake can improve glucose regulation in lean, aged male mice, and 2) these male mice also had decreased Glut4 and Insr expression in a diet low in vitamin D in various tissues indicating that dietary vitamin D may be a sex-specific key mediator in regulating glucose tolerance and protecting against insulin resistance.","journal":"The Journal of Steroid Biochemistry and Molecular Biology","year":2025,"id":581664,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1493236,"name":"María Teresa Vizcarra Morales","orcid":"0000-0002-9369-9740","position":1,"is_corresponding":false},{"id":384333,"name":"Ji Youn Youn","orcid":null,"position":2,"is_corresponding":false},{"id":267310,"name":"Yong Xu","orcid":"0000-0002-4908-1572","position":3,"is_corresponding":false},{"id":406167,"name":"Stephanie Sisley","orcid":"0000-0003-2900-7014","position":4,"is_corresponding":false},{"id":1258520,"name":"Olivia Z. Ginnard","orcid":"0000-0002-8175-6357","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:58:51.328454Z","pmid":"41242400","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}