{"doi":"10.1016/j.jsbmb.2023.106248","title":"Comparison of calcifediol with vitamin D for prevention or cure of vitamin D deficiency","abstract":null,"journal":"The Journal of Steroid Biochemistry and Molecular Biology","year":2023,"id":615365,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1586076,"name":"Jose Manuel Quesada Gomez","orcid":null,"position":1,"is_corresponding":false},{"id":217248,"name":"Roger Bouillon","orcid":"0000-0002-6446-3763","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Comparison of calcifediol with vitamin D for prevention or cure of vitamin D deficiency","abstract":"Vitamin D deficiency remains prevalent, with about 7% of the world's population living with severe vitamin D deficiency and about one third with mild deficiency. We compare the relative merits of calcifediol or 25-hydroxyvitamin D (25OHD) compared to vitamin D itself for supplementation as to prevent or cure vitamin D deficiency. The intestinal absorption of calcifediol is nearly 100% and thus higher than that of vitamin D itself. Moreover, calcifediol is absorbed by the intestinal cells and transported through the portal vein and thus immediately accessible to the circulation, while vitamin D is transported with chylomicrons through the lymph system. Therefore, in case of fat malabsorption or after bariatric surgery, calcifediol is much better absorbed in comparison with vitamin D itself. Serum 25OHD increases linearly with increasing doses of calcifediol, whereas serum 25OHD reaches a plateau when higher oral doses of vitamin D are used. Calcifediol, on a weight basis, is about 3 times more potent than vitamin D in subjects with mild vitamin D deficiency. This potency is even 6-8 times higher than vitamin D when baseline serum 25OHD is higher or when large doses are compared. In conclusion, calcifediol is an alternative option to correct vitamin D deficiency and may even be the preferred strategy in case of intestinal fat malabsorption, after bariatric surgery or in case of other conditions with suspected impaired 25-hydroxylase activity in the liver.","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36646151","pmcid":null,"openalex_id":"https://openalex.org/W4316035477","authors":[],"funders":[],"total_grants":0,"fwci":4.4006,"citation_percentile":0.95120808,"influential_citations":2,"citation_trend":[{"year":2023,"count":6},{"year":2024,"count":13},{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0960076023000031?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960076023000031?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jsbmb.2023.106248","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36646151","host_type":"repository"}],"fields_of_study":["Vitamin D Research Studies","Parathyroid Disorders and Treatments","Bone health and osteoporosis research","Medicine","Humans","Calcifediol","Vitamin D","Vitamins","Vitamin D Deficiency","Liver"],"mesh_terms":["Calcifediol","Humans","Liver","Vitamin D","Vitamin D Deficiency","Vitamins"],"keywords":["Calcifediol","Medicine","Vitamin D and neurology","Malabsorption","vitamin D deficiency","Internal medicine","Vitamin","Endocrinology","Cholecalciferol","Population","Vitamin D","intestinal absorption","25-hydroxyvitamin D","Bariatric Surgery","Cyp2r1"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.25036222.v1","title":"Additional file 1 of Highly selective whole-cell 25-hydroxyvitamin D3 synthesis using molybdenum-dependent C25-steroid dehydrogenase and cyclodextrin recycling","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.25036222","title":"Additional file 1 of Highly selective whole-cell 25-hydroxyvitamin D3 synthesis using molybdenum-dependent C25-steroid dehydrogenase and cyclodextrin recycling","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T19:47:57.266791Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}