{"doi":"10.1016/j.jsat.2020.02.010","title":"The National Drug Abuse Treatment Clinical Trials Network: From 2000 to 2020 and beyond","abstract":"This issue of the Journal of Substance Abuse Treatment reflects on and celebrates 20 years of investigations conducted within the National Drug Abuse Treatment Clinical Trials Network (CTN). The origins of the CTN lie in an Institute of Medicine (now Academy of Medicine) study committee that the Center for Substance Abuse Treatment and the National Institute on Drug Abuse (NIDA) commissioned to address the gap between research and practice in the treatment of alcohol and drug use disorders – Committee on Community-Based Drug Treatment (Institute of Medicine, 1998Institute of Medicine Bridging the gap between practice and research: Forging partnerships with community-based drug and alcohol treatment. National Academy Press, Washington, DC1998Google Scholar). The Committee's recommendations as a means of bridging this gap emerged in a consensus process and its first recommendation was …The National Institute on Drug Abuse and the Center for Substance Abuse Treatment should support the development of an infrastructure to facilitate research within a network of community-based treatment programs similar to the National Cancer Institute's Community Clinical Oncology Program networks (p. 6) (Institute of Medicine, 1998Institute of Medicine Bridging the gap between practice and research: Forging partnerships with community-based drug and alcohol treatment. National Academy Press, Washington, DC1998Google Scholar).This is the seed that found fertile soil and grew into the National Drug Abuse Treatment Clinical Trials Network. With the approval of the NIDA Director, Alan Leshner, NIDA issued a request for applications; an initial review of the applications identified seven applications for site visits and led to six founding cooperative agreement awards in 1999 and early 2000: Southern New England Node, New York Node, Delaware Valley Node, Mid-Atlantic Node, Pacific Node and Oregon Node. NIDA's Center for the Clinical Trials Network, the six founding nodes and their participating drug abuse treatment centers debated and collaborated to develop the initial seven CTN protocols to test opioid detoxification strategies using buprenorphine in inpatient and outpatient settings (CTN-0001, CTN-0002, CTN-0003), motivational interviewing and motivational effectiveness therapy in community-based outpatient centers (CTN-0004, CTN-0005) and contingency management to reduce stimulant use in opioid treatment programs and enhance retention in outpatient clinics (CTN-0006, CTN-0007). Investigators and the treatment centers considered the feasibility and practicality of different study designs and hypotheses that could be implemented without disruption of workflow. The protocols emerged in a unique and innovative integration of practice and research that formed the CTN's foundation and set the stage for more than two decades of pragmatic trials pushing the frontier of research and treatment. Over time and through five cycles of competing renewals, the Network grew, contracted and expanded. The CTN became more efficient and broadened its focus from treatment in specialty addiction treatment settings and began testing practice innovations in primary care clinics, emergency departments, acute care hospitals, HIV clinics and STD clinics. Data coordination and collection were centralized and consolidated with a data and statistics center that assumed responsibility for testing primary hypotheses. In 20 years, the CTN has completed 64 full protocols with 9 protocols active in the field and an additional 27 in development; the protocols have served as a platform for 40 ancillary and other sub-studies and R01 awards. To date, CTN investigations have generated 500 peer-reviewed publications. The CTN also hosts a data sharing site where CTN protocol data are posted and available for public use: https://datashare.nida.nih.gov/. Detailed information on study protocols and the papers based on CTN analyses are available in the CTN Dissemination library: http://ctndis","journal":"Journal of Substance Abuse Treatment","year":2020,"id":85521,"datarank":0.40716135160360856,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.13839743121940026,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.13839743121940026,"corpus_percentile":54.80776668987391,"corpus_rank":5843,"citation_count":5,"citer_count":5,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5262,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":437488,"name":"Dennis M. Donovan","orcid":"0000-0003-2237-4292","position":1,"is_corresponding":false},{"id":437487,"name":"Dennis McCarty","orcid":"0000-0001-9014-2894","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-18T21:58:16.217017Z","pmid":"32220404","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}