{"doi":"10.1016/j.jphs.2022.09.002","title":"Effects of a novel hepatitis B anti-viral drug E-CFCP in renal organic acid transporters","abstract":"Currently, the emergence of drug resistance is an important issue in the treatment of hepatitis B virus (HBV). Recently, our collaborating group developed a novel long-acting anti-HBV drug, E-CFCP. However, until this study, the effects of E-CFCP in the kidney have remained unclarified. Using cell viability and uptake assays, we examined the effects of E-CFCP on the function of renal organic anion transporters (OATs). No cytotoxicity was shown related to the E-CFCP in the renal OATs in either assay. Thus, this study suggested that E-CFCP may be a novel, excellent candidate drug for the treatment of drug-resistant HBV.","journal":"Journal of Pharmacological Sciences","year":2022,"id":288606,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":969375,"name":"Hirofumi Hashimoto","orcid":"0000-0003-1575-836X","position":1,"is_corresponding":false},{"id":969756,"name":"Meika Kaneko","orcid":null,"position":2,"is_corresponding":false},{"id":969376,"name":"Shota Saito","orcid":"0000-0002-4463-6073","position":3,"is_corresponding":false},{"id":969757,"name":"Sangjon Pae","orcid":null,"position":4,"is_corresponding":false},{"id":969377,"name":"Shinpei Saito","orcid":"0000-0002-9346-0553","position":5,"is_corresponding":false},{"id":969758,"name":"Yoshie Reien","orcid":null,"position":6,"is_corresponding":false},{"id":969378,"name":"Yuri Hirayama","orcid":"0000-0003-2366-2915","position":7,"is_corresponding":false},{"id":495658,"name":"Nobuyo Higashi‐Kuwata","orcid":"0000-0002-9404-3532","position":8,"is_corresponding":false},{"id":295833,"name":"Hiroaki Mitsuya","orcid":"0000-0001-9274-3853","position":9,"is_corresponding":false},{"id":969379,"name":"Naohiko Anzai","orcid":"0000-0003-0605-0458","position":10,"is_corresponding":false},{"id":969755,"name":"Misaki Ishibane","orcid":null,"position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-19T00:30:14.968626Z","pmid":"36344041","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}