{"doi":"10.1016/j.jphs.2022.07.004","title":"HDL, cholesterol efflux, and ABCA1: Free from good and evil dualism","abstract":null,"journal":"Journal of Pharmacological Sciences","year":2022,"id":592788,"datarank":0.9716609230907389,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"self_citation_contribution":0.5333022092234121,"citation_network_contribution":0.43835871386732683,"self_endowment_contribution":0.5333022092234121,"citer_contribution":0.43835871386732683,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":32,"citers_with_citation_signal":22,"citers_with_endowment":22,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1516988,"name":"Masatsune Ogura","orcid":"0000-0002-7247-1448","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"HDL, cholesterol efflux, and ABCA1: Free from good and evil dualism","abstract":"Homozygotes for loss-of-function mutations in ABCA1 cause Tangier disease. The phenotype of their markedly reduced or loss of blood high-density lipoprotein (HDL) cholesterol, as well as examination of ATP-binding cassette transporter A1 (ABCA1)-deficient mice, proved that ABCA1 is a key player in HDL production. The ABCA1-mediated cholesterol efflux is the first step in the reverse cholesterol transport system and understanding the regulation of its expression was expected to lead to the development of anti-atherosclerotic drugs. However, from the viewpoint of intracellular cholesterol homeostasis, it is difficult to say that simple activation of ABCA1 or promotion of cholesterol efflux is a good strategy. To date, there is no evidence that HDL-increasing drugs by enhancing ABCA1 expression prevent atherosclerotic disease in humans. On the other hand, in situations where intracellular cholesterol homeostasis is disrupted by inflammation, aging, or metabolic abnormalities, a strategy that restores reduced ABCA1 expression and cholesterol efflux in a timely and localized manner may be useful.","is_dataset_classified":null,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36055755","pmcid":null,"openalex_id":"https://openalex.org/W4289948689","authors":[],"funders":[{"funder_name":"Japan Society for the Promotion of Science","grant_id":"JP15K09130","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"JP18K08125","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"21H03821","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"21K08143","title":null},{"funder_name":"JPS","grant_id":"","title":null},{"funder_name":"SENSHIN Medical Research Foundation","grant_id":"","title":null},{"funder_name":"Ono Medical Research Foundation","grant_id":"","title":null}],"total_grants":7,"fwci":5.8791,"citation_percentile":0.97249573,"influential_citations":0,"citation_trend":[{"year":2023,"count":7},{"year":2024,"count":10},{"year":2025,"count":11},{"year":2026,"count":6}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.jphs.2022.07.004","host_type":"journal"},{"url":"https://doi.org/10.1016/j.jphs.2022.07.004","host_type":"GOLD"},{"url":"https://doi.org/10.1016/j.jphs.2022.07.004","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1347861322000548?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1347861322000548?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36055755","host_type":"repository"},{"url":"https://doaj.org/article/78ac949d62c541238685335b80cd8884","host_type":"repository"}],"fields_of_study":["Cholesterol and Lipid Metabolism","Drug Transport and Resistance Mechanisms","Lipoproteins and Cardiovascular Health","Medicine","Biology","ATP Binding Cassette Transporter 1","ATP-Binding Cassette Transporters","Animals","Atherosclerosis","Biological Transport","Cholesterol","Cholesterol, HDL","Humans","Lipoproteins, HDL","Mice"],"mesh_terms":["Animals","Biological Transport","Cholesterol","Humans","Lipoproteins, HDL","Cholesterol, HDL","ATP-Binding Cassette Transporters","Atherosclerosis","Mice","ATP Binding Cassette Transporter 1"],"keywords":["ABCA1","Reverse cholesterol transport","Tangier disease","ATP Binding Cassette Transporter 1","Efflux","Cholesterol","Transporter","Biology","Homeostasis","Cell biology","Chemistry","Endocrinology","Lipoprotein","Biochemistry","Gene","HDL","Cholesterol efflux","drug discovery","Intracellular Cholesterol Homeostasis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T15:32:32.042094Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}