{"doi":"10.1016/j.jpeds.2025.114544","title":"Can We Optimize Retinopathy of Prematurity Screening by Combined Risk Score Analysis?","abstract":null,"journal":"The Journal of Pediatrics","year":2025,"id":615846,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":696694,"name":"Daniel York","orcid":"0000-0001-6286-2894","position":1,"is_corresponding":false},{"id":1294277,"name":"Sravanthi Vegunta","orcid":"0000-0002-1476-4701","position":2,"is_corresponding":false},{"id":1587533,"name":"Carrie Torr","orcid":null,"position":3,"is_corresponding":false},{"id":230770,"name":"Bradley A. Yoder","orcid":"0000-0003-0904-9778","position":4,"is_corresponding":false},{"id":303015,"name":"Emma Banwell","orcid":"0009-0007-9486-3198","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Can We Optimize Retinopathy of Prematurity Screening by Combined Risk Score Analysis?","abstract":"<h4>Objective</h4>To evaluate a composite metric incorporating the DIGIROP-Birth (DRB) and Neonatal Research Network Bronchopulmonary Dysplasia Outcome Estimator (NRN-BPD) for predicting severe retinopathy of prematurity requiring treatment (TR-ROP).<h4>Study design</h4>This was a retrospective cohort study of 990 infants born prematurely undergoing dilated eye examinations between January 2010 and August 2023. We performed a chart review to assess a primary outcome of TR-ROP and secondary outcome of stage 2 or greater ROP. DRB and 14-day NRN-BPD scores were quantified for each infant, and optimal thresholds for predicting TR-ROP were analyzed using receiver operator characteristic curves. Sensitivity and specificity for TR-ROP were assessed.<h4>Results</h4>Of the 990 infants, 364 (36.8%) had stage 2 or greater ROP and 68 (6.9%) had TR-ROP. Receiver operator characteristic analysis with (95% CI) showed areas under the curve of 0.867 (0.829-0.906) for DRB and 0.845 (0.809-0.881) for NRN-BPD. Optimal cutoff scores were 1.7 for DRB and 40% for NRN-BPD with respective sensitivities of 97% and 96%. Composite screening for babies meeting either cutoff allowed 100% sensitivity for predicting TR-ROP while decreasing number of infants qualifying for screening from 990 to 562 (43% reduction).<h4>Conclusions</h4>A composite metric using DigiROP-Birth and NRN-BPD Outcome Estimator scores may allow an early, simple approach to predict TR-ROP with 100% sensitivity yet allow significant reduction in the number of infants requiring screening eye examinations. Additional large validation studies are needed.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40113074","pmcid":null,"openalex_id":"https://openalex.org/W4408567743","authors":[],"funders":[],"total_grants":0,"fwci":0.8661,"citation_percentile":0.70553682,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0022347625000848?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022347625000848?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jpeds.2025.114544","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40113074","host_type":"repository"}],"fields_of_study":["Retinopathy of Prematurity Studies","Neonatal Respiratory Health Research","Infant Development and Preterm Care"],"mesh_terms":["Female","Gestational Age","Humans","Infant, Newborn","Infant, Premature","Male","Retinopathy of Prematurity","Retrospective Studies","ROC Curve","Sensitivity and Specificity","Neonatal Screening","Risk Assessment"],"keywords":["Medicine","Retinopathy of prematurity","Pediatrics","Gestational age","Pregnancy","Screening","prematurity","Bronchopulmonary Dysplasia"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T21:13:41.249288Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}