{"doi":"10.1016/j.jpeds.2014.08.041","title":"Quantitative Trait Analysis of Polymorphisms in Two Bilirubin Metabolism Enzymes to Physiologic Bilirubin Levels in Chinese Newborns","abstract":null,"journal":"The Journal of Pediatrics","year":2014,"id":664524,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1735149,"name":"San-nan Wang","orcid":null,"position":1,"is_corresponding":false},{"id":752337,"name":"Hong Li","orcid":"0000-0002-8333-5361","position":2,"is_corresponding":false},{"id":1735151,"name":"Weifeng Zha","orcid":null,"position":3,"is_corresponding":false},{"id":857046,"name":"Qianqian Peng","orcid":null,"position":4,"is_corresponding":false},{"id":669052,"name":"Shilin Li","orcid":"0000-0001-7065-6150","position":5,"is_corresponding":false},{"id":404402,"name":"Ying Chen","orcid":"0000-0003-3966-2725","position":6,"is_corresponding":false},{"id":1465399,"name":"Li Jin","orcid":"0000-0002-4322-8238","position":7,"is_corresponding":false},{"id":1735148,"name":"Youyou Zhou","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Quantitative Trait Analysis of Polymorphisms in Two Bilirubin Metabolism Enzymes to Physiologic Bilirubin Levels in Chinese Newborns","abstract":"<h4>Objective</h4>To explore the effects of variants in Uridine Diphosphate Glucuronosyl Transferase 1A1 (UGT1A1) and Heme Oxygenase-1 (HMOX1) on daily physiological bilirubin levels and bilirubin changes during the first week after birth in Chinese newborns. Both UGT1A1 and HMOX1 code rate-limiting enzymes in the bilirubin metabolism pathway.<h4>Study design</h4>We conducted a retrospective quantitative trait study to analyze 4154 daily bilirubin values, 3129 bilirubin changes, and 11 polymorphisms of 988 newborns during the natural course of physiological hyperbilirubinemia.<h4>Results</h4>For UGT1A1, we found minor allele A of rs4148323 (G211A, UGT1A1*6) contributed to higher daily bilirubin levels on days 4-6 (with contributions to variations increasing from 4.8% to 12.3%), minor allele T of rs887829 (c-364t) contributed to lower daily bilirubin levels for days 6 and 7 (with contributions to variations increasing from 7.0% to 10.2%) (P < .03 for all). In addition, minor alleles of rs887829 and (TA)n repeat (UGT1A1*28), and haplotype T-long-G at rs887829-(TA)n-rs4148323 were associated with a decrease in bilirubin levels from day 5 to day 6 (P < .01 for all). No contribution from HMOX1 was found.<h4>Conclusion</h4>Bilirubin levels and changes during the middle and late parts of the first week were attributed to variants and haplotypes in UGT1A1. This quantitative trait study may provide a more robust statistical method for determining the association of genetic factors and bilirubin kinetics to predict the development of neonatal bilirubin in early postnatal life.","is_dataset_classified":null,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25262300","pmcid":null,"openalex_id":"https://openalex.org/W2046731925","authors":[],"funders":[],"total_grants":0,"fwci":3.1031,"citation_percentile":0.91502399,"influential_citations":0,"citation_trend":[{"year":2015,"count":3},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2018,"count":2},{"year":2019,"count":1},{"year":2020,"count":3},{"year":2021,"count":9},{"year":2022,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0022347614007884?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022347614007884?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jpeds.2014.08.041","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25262300","host_type":"repository"}],"fields_of_study":["Neonatal Health and Biochemistry","Heme Oxygenase-1 and Carbon Monoxide","Porphyrin Metabolism and Disorders"],"mesh_terms":["UGT1A1 Enzyme","Bilirubin","Female","Genotype","Haplotypes","Humans","Infant, Newborn","Jaundice, Neonatal","Male","Retrospective Studies","Glucuronosyltransferase","Genetic Variation","Asian People","Heme Oxygenase-1"],"keywords":["Bilirubin","HMOX1","Glucuronosyltransferase","Medicine","Internal medicine","Physiology","Heme","Metabolism","Endocrinology","Heme oxygenase","Biochemistry","Biology","Enzyme","Microsome"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"refsnp"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T03:14:49.087578Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}