{"doi":"10.1016/j.jpain.2024.01.001","title":"Reduced Gray Matter Volume and Cortical Thickness in Patients With Small-Fiber Neuropathy","abstract":null,"journal":"The Journal of Pain","year":2024,"id":651267,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":760630,"name":"Maike F. 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Central correlates have been identified on the level of gray matter volume (GMV) and cortical thickness (CT) changes. However, across SFN etiologies knowledge about a common structural brain signature is still lacking. Therefore, we recruited 26 SFN patients and 25 age- and sex-matched healthy controls to conduct voxel-based- and surface-based morphometry. Across all patients, we found reduced GMV in widespread frontal regions, left caudate, insula and superior parietal lobule. Surface-based morphometry analysis revealed reduced CT in the right precentral gyrus of SFN patients. In a region-based approach, patients had reduced GMV in the left caudate. Since pathogenic gain-of-function variants in voltage-gated sodium channels (Nav) have been associated with SFN pathophysiology, we explored brain morphological patterns in a homogenous subsample of patients carrying rare heterozygous missense variants. Whole brain- and region-based approaches revealed GMV reductions in the bilateral caudate for Nav variant carriers. Further research is needed to analyze the specific role of Nav variants for structural brain alterations. Together, we conclude that SFN patients have specific GMV and CT alterations, potentially forming potential new central biomarkers for this condition. Our results might help to better understand underlying or compensatory mechanisms of chronic pain perception in the future. PERSPECTIVE: This study reveals structural brain changes in small-fiber neuropathy (SFN) patients, particularly in frontal regions, caudate, insula, and parietal lobule. Notably, individuals with SFN and specific Nav variants exhibit bilateral caudate abnormalities. These findings may serve as potential central biomarkers for SFN and provide insights into chronic pain perception mechanisms.","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38211845","pmcid":null,"openalex_id":"https://openalex.org/W4390776643","authors":[],"funders":[{"funder_name":"National Research Foundation of Korea","grant_id":"2023K2A9A2A22000113","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"368482240/GRK2416","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"RTG 2416","title":null},{"funder_name":"RWTH Aachen University","grant_id":"IZKF TN1-8/IA 532008","title":null},{"funder_name":"RWTH Aachen University","grant_id":"IZKF TN1-2/IA 532002","title":null},{"funder_name":"RWTH Aachen University","grant_id":"IZKF TN1-6/IA 532006","title":null},{"funder_name":"RWTH Aachen University","grant_id":"IZKF TN1-1/IA 532001","title":null},{"funder_name":"RWTH Aachen University","grant_id":"IZKF TN1-9/IA 532009","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"},{"funder_name":"RWTH Aachen University Medical Faculty","grant_id":"","title":null},{"funder_name":"Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg","grant_id":"","title":null}],"total_grants":11,"fwci":1.667,"citation_percentile":0.83041008,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":4},{"year":2026,"count":2}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"http://www.jpain.org/article/S1526590024000105/pdf","host_type":"journal"},{"url":"http://www.jpain.org/article/S1526590024000105/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1526590024000105?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1526590024000105?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jpain.2024.01.001","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38211845","host_type":"repository"},{"url":"https://dx.doi.org/10.18154/rwth-2024-01146","host_type":""},{"url":"https://dx.doi.org/10.34734/fzj-2024-02748","host_type":""},{"url":"https://juser.fz-juelich.de/record/1025171","host_type":""},{"url":"https://publications.rwth-aachen.de/record/978119","host_type":""}],"fields_of_study":["Pain Mechanisms and Treatments","Botulinum Toxin and Related Neurological Disorders","Advanced Neuroimaging Techniques and Applications","03 medical and health sciences","0302 clinical medicine","Humans","Male","Gray Matter","Female","Middle Aged","Small Fiber Neuropathy","Adult","Cerebral Cortex","Aged","Magnetic Resonance Imaging","Brain Cortical Thickness"],"mesh_terms":["Small Fiber Neuropathy","Brain Cortical Thickness","Adult","Aged","Cerebral Cortex","Female","Humans","Magnetic Resonance Imaging","Male","Middle Aged","Gray Matter"],"keywords":["Precentral gyrus","Insula","Caudate nucleus","Medicine","Inferior parietal lobule","Voxel-based morphometry","Neuroscience","Middle frontal gyrus","Pathology","Magnetic resonance imaging","Internal medicine","Psychology","White matter","Cognition","Radiology","Cortical Thickness","Gray Matter Volume","Surface-based Morphometry","Small-fiber Neuropathy","Male","Adult","Cerebral Cortex","Small Fiber Neuropathy","610","Middle Aged","Brain Cortical Thickness","Humans","Female","Gray Matter","info:eu-repo/classification/ddc/610","Aged"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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