{"doi":"10.1016/j.jocd.2025.101605","title":"Changes in lean mass and fat mass in children with Osteogenesis Imperfecta","abstract":null,"journal":"Journal of Clinical Densitometry","year":2025,"id":622531,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1431323,"name":"Sze Choong Wong","orcid":"0000-0003-2845-6555","position":1,"is_corresponding":false},{"id":1608552,"name":"Misha Gilani","orcid":"0000-0001-7174-4080","position":2,"is_corresponding":false},{"id":1608554,"name":"Helen McDevitt","orcid":null,"position":3,"is_corresponding":false},{"id":1608556,"name":"Sheila Shepherd","orcid":null,"position":4,"is_corresponding":false},{"id":1608558,"name":"Avril Mason","orcid":null,"position":5,"is_corresponding":false},{"id":1608549,"name":"Holly Wright","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Changes in lean mass and fat mass in children with Osteogenesis Imperfecta","abstract":"<h4>Background</h4>Deficits in skeletal muscle and function, with resultant abnormal body composition, is a recognised feature of Osteogenesis Imperfecta (OI). Less is known about longitudinal change in body composition in OI. Our objective was to perform a retrospective analysis of longitudinal change in body composition (lean mass and fat mass) in children with OI.<h4>Methodology</h4>Data was collected from 29 children, with a diagnosis of OI, who had at least two dual-energy x-ray absorptiometry (DXA) scans performed between 2015 and 2022. Assessed variables of height, body mass index (BMI), lean mass index (LMI) and fat mass index (FMI), were converted to z scores. Results were reported as median (range).<h4>Results</h4>Median age at baseline and follow-up were 10.7 and 14.2 years, respectively. Median height z-score at baseline was -1.10, which was significantly lower than a control population (p<0.001). Median height z-score at latest follow-up was -0.80, which was not significantly different from baseline (p=0.870). Median BMI z-score at baseline was 0.15, which was not significantly different than a control population (p=0.804). Median BMI z-score at latest follow-up was 0.02, which was not significantly different from baseline (p=0.730). At baseline, median LMI z-score was -2.43, which was significantly lower than a control population (p<0.001). Median LMI z-score at follow-up was -1.78, which was not significantly different from baseline (p=0.080). At baseline, median FMI z-score was 0.57 which was significantly higher than a control population (p=0.001). Median FMI z-score at follow-up was 0.62, which was not significantly different from baseline (p=0.540).<h4>Conclusion</h4>Children with OI have abnormal body composition throughout childhood typically with low lean mass and relatively high fat mass. These abnormalities in body composition do not change with follow-up. Strategies to improve lean mass, including physical or medical therapies, should be explored in OI given the close relationship between muscle and bone.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40682903","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.jocd.2025.101605","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1094695025000459?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1094695025000459?httpAccept=text/plain","host_type":"publisher"},{"url":"https://eprints.gla.ac.uk/359439/1/359439.pdf","host_type":"repository"}],"fields_of_study":["Humans","Osteogenesis Imperfecta","Child","Male","Female","Retrospective Studies","Absorptiometry, Photon","Adolescent","Body Composition","Body Mass Index","Adipose Tissue","Muscle, Skeletal","Child, Preschool","Body Height","Longitudinal Studies"],"mesh_terms":["Muscle, Skeletal","Adipose Tissue","Humans","Osteogenesis Imperfecta","Absorptiometry, Photon","Body Mass Index","Body Height","Retrospective Studies","Longitudinal Studies","Body Composition","Adolescent","Child","Child, Preschool","Female","Male"],"keywords":["Body composition","Osteogenesis imperfecta","Lean Mass"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T19:58:58.398734Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}