{"doi":"10.1016/j.jocd.2012.05.007","title":"Validation of the FRAX Predictive Model for Major Osteoporotic Fracture in a Historical Cohort of Spanish Women","abstract":null,"journal":"Journal of Clinical Densitometry","year":2013,"id":603878,"datarank":0.5456379239589579,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":0.0,"self_endowment_contribution":0.5456379239589579,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1549219,"name":"Luís Miguel del Río","orcid":null,"position":1,"is_corresponding":false},{"id":1549220,"name":"Silvana Di Gregorio","orcid":null,"position":2,"is_corresponding":false},{"id":1549222,"name":"Lidia Casas","orcid":null,"position":3,"is_corresponding":false},{"id":1549224,"name":"Maria-Dolors Estrada","orcid":null,"position":4,"is_corresponding":false},{"id":1549225,"name":"Anna Kotzeva","orcid":null,"position":5,"is_corresponding":false},{"id":1549226,"name":"Mireia Espallargues","orcid":null,"position":6,"is_corresponding":false},{"id":1549218,"name":"Cristian Tebé Cordomí","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Validation of the FRAX Predictive Model for Major Osteoporotic Fracture in a Historical Cohort of Spanish Women","abstract":"FRAX is a fracture risk assessment tool to estimate the 10-yr probability of a major osteoporotic fracture or a hip fracture. The aim of the study was to assess the predictive ability of FRAX for major osteoporotic fracture in a cohort of Spanish women. The study was based on a retrospective cohort of women aged 40-90 yr. Patients were followed from their first bone densitometry to the first major osteoporotic fracture event (forearm, proximal humerus, clinical spine, or hip fracture) or for 10 yr whichever comes first. A total of 1231 women were included. Bone mineral density data and self-reported data on risk factors for fracture were obtained. The predictive ability of FRAX was assessed by analyzing calibration and discrimination, with the calculation of observed-to-expected (O/E) fracture ratios and the receiver operating characteristic (ROC) curve, respectively. A total of 222 women (18.1%) reported at least 1 fracture after the first assessment. The incidence of fracture was 14 (95% confidence interval [CI]: 10-17), 19 (95% CI: 15-23), 28 (95% CI: 21-36), and 67 (95% CI: 8-125) cases per 1000 woman-years in women aged <55, 55-64, 65-74, and ≥75 yr, respectively. The O/E ratio was 3.9 (95% CI: 3.4-4.5; p<0.0001). The area under the ROC curve was 61% (95% CI: 57-65%). FRAX underestimated the risk of major osteoporotic fracture in this cohort of Spanish women, particularly in those with a low risk of fracture according to the clinical factors used in the FRAX tool. Our findings highlight the need for validation studies of FRAX in Spain.","is_dataset_classified":null,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22748778","pmcid":null,"openalex_id":"https://openalex.org/W2043387965","authors":[],"funders":[],"total_grants":0,"fwci":3.1521,"citation_percentile":0.90204403,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":2},{"year":2014,"count":2},{"year":2015,"count":8},{"year":2016,"count":3},{"year":2018,"count":1},{"year":2019,"count":5},{"year":2020,"count":2},{"year":2022,"count":4},{"year":2023,"count":4},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.1016/j.jocd.2012.05.007","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22748778","host_type":"repository"}],"fields_of_study":["Bone health and osteoporosis research","Bone health and treatments","Hip and Femur Fractures"],"mesh_terms":["Adult","Aged","Female","Hip Fractures","Humans","Middle Aged","Risk Factors","ROC Curve","Spain","Bone Density","Spinal Fractures","Risk Assessment","Area Under Curve","Osteoporotic Fractures"],"keywords":["Medicine","FRAX","Osteoporotic fracture","Cohort","Cohort study","Osteoporosis","Internal medicine","Bone mineral"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Gender equality"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T22:54:37.445811Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}