{"doi":"10.1016/j.joca.2024.05.009","title":"Effect of isometric quadriceps exercise on local microcirculation of the infrapatellar fat pad in female patients with knee osteoarthritis","abstract":null,"journal":"Osteoarthritis and Cartilage","year":2024,"id":644643,"datarank":0.4825897525005214,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.10985375503232123,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.10985375503232123,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":8,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1678071,"name":"Masahiro Tsutsumi","orcid":"0000-0003-1803-8202","position":1,"is_corresponding":false},{"id":1678072,"name":"Masashi Kitano","orcid":null,"position":2,"is_corresponding":false},{"id":1678073,"name":"Takashi Kitagawa","orcid":null,"position":3,"is_corresponding":false},{"id":1678074,"name":"Toshinori Miyashita","orcid":null,"position":4,"is_corresponding":false},{"id":831998,"name":"Makoto Wada","orcid":"0000-0003-4222-9762","position":5,"is_corresponding":false},{"id":1678075,"name":"Shintarou Kudo","orcid":"0000-0001-9483-1830","position":6,"is_corresponding":false},{"id":1678070,"name":"Syoya Nakanishi","orcid":"0000-0002-2203-3108","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effect of isometric quadriceps exercise on local microcirculation of the infrapatellar fat pad in female patients with knee osteoarthritis","abstract":"OBJECTIVE: To elucidate the local microcirculation of the infrapatellar fat pad (IFP) in patients with knee osteoarthritis (KOA) by determining the changes in IFP hardness and hemoglobin concentration during isometric quadriceps exercise (IQE). DESIGN: In this observational cross-sectional study, patients diagnosed with bilateral KOA were included in the KOA group (30 knees), healthy older adults in the control group (20 knees), and younger adults in the young group (20 knees). Ultrasonography was performed at rest and during IQE to measure IFP hardness based on shear wave velocity. Near-infrared spectroscopy was performed to measure oxygenated hemoglobin (O2Hb), deoxygenated hemoglobin (HHb), and total hemoglobin (cHb) in the IFP before (Baseline), during (IQE task), and after IQE (Post). IFP hardness and O2Hb, HHb, and cHb concentration were analyzed using a linear mixed model for the groups and measurement points. RESULTS: During IQE, IFP hardness changes were significantly less in the KOA group than in the other groups (KOA: 95 % confidence intervals (CIs) [-0.854, 0.028]; control: 95 % CI [-0.941, -0.341]; and young: 95 % CI [-2.305, -1.706]). In the KOA group, O2Hb concentration exhibited no significant changes at Post compared with Baseline; however, significant changes were observed in the other groups (KOA: 95 % CI [-1.176, 0.423]; control: 95 % CI [-1.452, -0.276]; and young: 95 % CI [-4.062, -2.102]). CONCLUSIONS: During IQE, changes in hardness and hemoglobin concentration in the IFP were not significant in the KOA group, suggesting impaired local microcirculation of the IFP.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38824995","pmcid":null,"openalex_id":"https://openalex.org/W4399207532","authors":[],"funders":[],"total_grants":0,"fwci":3.6321,"citation_percentile":0.93046385,"influential_citations":0,"citation_trend":[{"year":2024,"count":2},{"year":2025,"count":6},{"year":2026,"count":2}],"oa_status":"hybrid","license":"other-oa","oa_locations":[{"url":"https://www.oarsijournal.com/article/S1063-4584(24)01208-1/pdf","host_type":"journal"},{"url":"https://www.oarsijournal.com/article/S1063-4584(24)01208-1/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1063458424012081?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1063458424012081?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.joca.2024.05.009","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38824995","host_type":"repository"}],"fields_of_study":["Osteoarthritis Treatment and Mechanisms","Total Knee Arthroplasty Outcomes","Lower Extremity Biomechanics and Pathologies","Humans","Female","Osteoarthritis, Knee","Cross-Sectional Studies","Quadriceps Muscle","Middle Aged","Adipose Tissue","Microcirculation","Aged","Adult","Spectroscopy, Near-Infrared","Ultrasonography","Exercise","Hemoglobins","Isometric Contraction","Case-Control Studies","Patella","Young Adult"],"mesh_terms":["Adipose Tissue","Adult","Aged","Cross-Sectional Studies","Female","Hemoglobins","Humans","Isometric Contraction","Microcirculation","Middle Aged","Patella","Ultrasonography","Exercise","Case-Control Studies","Spectroscopy, Near-Infrared","Osteoarthritis, Knee","Quadriceps Muscle","Young Adult"],"keywords":["Infrapatellar fat pad","Isometric exercise","Osteoarthritis","Medicine","Microcirculation","Fat pad","Cardiology","Internal medicine","Adipose tissue","Pathology","fibrosis","Knee Osteoarthritis","Local Microcirculation","Isometric Quadriceps Exercise"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Gender equality"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T01:44:47.569096Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}