{"doi":"10.1016/j.joca.2022.10.023","title":"Association between weight gain and knee osteoarthritis: a systematic review","abstract":null,"journal":"Osteoarthritis and Cartilage","year":2023,"id":608971,"datarank":0.9896003186910738,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.4520724779226572,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.4520724779226572,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":33,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1564735,"name":"S.M. Hussain","orcid":null,"position":1,"is_corresponding":false},{"id":897765,"name":"J. Abidi","orcid":null,"position":2,"is_corresponding":false},{"id":544757,"name":"J. Cheng","orcid":null,"position":3,"is_corresponding":false},{"id":1564736,"name":"J.L. Fairley","orcid":"0000-0003-4140-2711","position":4,"is_corresponding":false},{"id":1564737,"name":"M.J. Page","orcid":null,"position":5,"is_corresponding":false},{"id":1564738,"name":"F.M. Cicuttini","orcid":null,"position":6,"is_corresponding":false},{"id":980026,"name":"Anita E. Wluka","orcid":"0000-0001-8024-9049","position":7,"is_corresponding":false},{"id":1564734,"name":"P. Solanki","orcid":"0000-0002-5868-3962","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Association between weight gain and knee osteoarthritis: a systematic review","abstract":"<h4>Objective</h4>Although weight loss is recommended to manage knee osteoarthritis (KOA), adults tend to gain weight with age which may affect KOA symptoms and progression. We conducted a systematic review and data synthesis to investigate the association between weight gain and KOA, defined by clinical features, structural progression, and total knee replacement (TKR).<h4>Design</h4>MEDLINE and EMBASE were systematically searched for controlled trials and cohort studies of participants with (or at risk of) KOA examining the relationship between weight gain and KOA clinical features (pain, function, quality of life), structural progression, and TKR. Risk of bias was assessed using the ROBINS-I tool. Results were organised by outcome, with meta-analyses performed where appropriate.<h4>Results</h4>Twenty-three studies were included. Results showed significant detrimental effects of weight gain on pain (4 of 7 studies), stiffness (2 of 2 studies), function (5 of 6 studies), and the single studies examining quality of life, and clinical and radiographic KOA. Weight gain adversely affected cartilage (6 of 9 studies), bone marrow lesions (1 of 4 studies), meniscal damage (1 of 3 studies) and effusion/synovitis (1 of 1 study). Weight gain significantly increased TKR (3 of 6 studies): meta-analysis of 2 with available data demonstrated significant increases in TKR/5 kg weight gain in women, HR 1.34 (95% CI 1.18-1.51), and in men, HR 1.25 (95% CI 1.16-1.34).<h4>Conclusions</h4>Weight gain in adults is associated with increased clinical and structural KOA and TKR. Prevention of weight gain should be considered to improve outcomes in KOA.","is_dataset_classified":null,"base_score":3.58351893845611,"endowment":3.58351893845611,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36511280","pmcid":null,"openalex_id":"https://openalex.org/W4310014542","authors":[],"funders":[{"funder_name":"Australian Research Council","grant_id":"DE200101618","title":"Discovery Early Career Researcher Award - Grant ID: DE200101618"},{"funder_name":"Australian Research Council","grant_id":"APP1194829","title":null},{"funder_name":"National Health and Medical Research Council","grant_id":"APP1142198","title":null},{"funder_name":"National Health and Medical Research Council","grant_id":"GNT2013842","title":null},{"funder_name":"Australian Government Department of Health","grant_id":"","title":null}],"total_grants":5,"fwci":2.1212,"citation_percentile":0.86785714,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":4},{"year":2024,"count":7},{"year":2025,"count":15},{"year":2026,"count":8}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.oarsijournal.com/article/S1063458422009335/pdf","host_type":"journal"},{"url":"http://www.oarsijournal.com/article/S1063458422009335/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1063458422009335?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1063458422009335?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.joca.2022.10.023","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36511280","host_type":"repository"},{"url":"https://doi.org/https://doi.org/10.1016/j.joca.2022.10.023","host_type":""}],"fields_of_study":["Osteoarthritis Treatment and Mechanisms","Total Knee Arthroplasty Outcomes","Lower Extremity Biomechanics and Pathologies","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Adult","Bone Diseases","Cartilage Diseases","Female","Humans","Male","Pain","Quality of Life","Cohort Studies","Arthroplasty, Replacement, Knee","Osteoarthritis, Knee"],"keywords":["Osteoarthritis","Association (psychology)","Medicine","Physical medicine and rehabilitation","Physical therapy","Psychology","Alternative medicine","Pathology","Structure","Pain","weight gain","Knee Osteoarthritis","Tkr","Adult","Male","610","Osteoarthritis, Knee","Cohort Studies","Quality of Life","Humans","Female","Bone Diseases","Arthroplasty, Replacement, Knee","Cartilage Diseases"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-31T01:27:23.903765Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}