{"doi":"10.1016/j.jns.2018.01.042","title":"Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in patients with optic neuritis and seizures","abstract":null,"journal":"Journal of the Neurological Sciences","year":2018,"id":662692,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1730105,"name":"Mark Kupersmith","orcid":null,"position":1,"is_corresponding":false},{"id":623584,"name":"Steven Galetta","orcid":"0000-0003-3781-7324","position":2,"is_corresponding":false},{"id":529976,"name":"Ilya Kister","orcid":"0000-0003-3549-949X","position":3,"is_corresponding":false},{"id":1730104,"name":"Josef Maxwell Gutman","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in patients with optic neuritis and seizures","abstract":"We describe four patients who experienced optic neuritis (ON) and seizures and were found to have antibodies to myelin oligodendrocyte glycoprotein (MOG) in serum. The index case was a previously healthy 39-year-old man who developed steroid dependent ON and had a generalized seizure when steroids were tapered. He tested positive for antibodies to MOG. We have reviewed the charts of all 11 anti-MOG antibody positive patients in our practice and found that 4 patients, all of whom had experienced one or more episodes of ON, also had a generalized seizure during the course of their illness. In 2 patients - including the index case - seizure occurred during steroid taper and in 2 others at the time of an episode of acute disseminated encephalomyelitis (ADEM). Association of anti-MOG antibodies and relapsing demyelinating disorders of the central nervous system is increasingly recognized. Testing for anti-MOG antibodies should be considered in patients with optic neuritis and seizures, especially in those with who also have a history of ADEM.","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29571858","pmcid":null,"openalex_id":"https://openalex.org/W2793559321","authors":[],"funders":[{"funder_name":"National Multiple Sclerosis Society","grant_id":"","title":null},{"funder_name":"Serono","grant_id":"","title":null},{"funder_name":"Biogen Idec","grant_id":"","title":null},{"funder_name":"Guthy-Jackson Charitable Foundation","grant_id":"","title":null},{"funder_name":"Novartis","grant_id":"","title":null},{"funder_name":"Genzyme","grant_id":"","title":null}],"total_grants":6,"fwci":2.4213,"citation_percentile":0.88583168,"influential_citations":0,"citation_trend":[{"year":2018,"count":2},{"year":2019,"count":5},{"year":2020,"count":5},{"year":2021,"count":4},{"year":2022,"count":3},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0022510X18300583?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022510X18300583?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jns.2018.01.042","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29571858","host_type":"repository"}],"fields_of_study":["Multiple Sclerosis Research Studies","Peripheral Neuropathies and Disorders","Systemic Lupus Erythematosus Research"],"mesh_terms":["Adult","Antibodies","Brain","Child","Child, Preschool","Female","Humans","Magnetic Resonance Imaging","Male","Optic Neuritis","Seizures","Myelin-Oligodendrocyte Glycoprotein"],"keywords":["Myelin oligodendrocyte glycoprotein","Optic neuritis","Acute disseminated encephalomyelitis","Medicine","Multiple sclerosis","Antibody","Myelin","Immunology","Pediatrics","Internal medicine","Central nervous system","Experimental autoimmune encephalomyelitis","Seizure","Myelin Oligodendrocyte Glycoprotein (Mog)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T16:57:33.175553Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}